"Synthetic Biology" and other key special project declaration guidelines for 2019.

State Science and Technology Development (2019) No. 195 provinces, autonomous regions, municipalities directly under the Central Government and the planning of the single-listed municipal science and technology department (commission, bureau), Xinjiang Production and Construction Corps Science and Technology Bureau, the State Council of the relevant departments of science and technology, the relevant units: according to the State Council issued "on deepening the central financial science and technology plan (special, fund, etc.) management reform program" (Cpc(2014) No. 64) the overall deployment of the "On the encouragement of the Hong Kong Special Administrative Region, the Macao Special Administrative Region, On the basis of the opening-up of the National Key Research and Development Program to Hong Kong and Macao on the basis of the pilot of the opening of the national key research and development plan to Hong Kong and Macao in 2018, three key special projects such as "synthetic biology" will continue to be opened to the Hong Kong and Macao Special Administrative Regions, and hong Kong and Macao universities are encouraged to jointly declare with mainland units, and will now publish the 2019 project declaration guidelines.
please organize project declarations in accordance with the requirements of the guidelines.
notification of the relevant matters is as follows.
. Project Organization Declaration Workflow 1. The reporting unit shall organize the declaration in the form of a project in accordance with the research content of the direction supported by the Guide, and the project may be organized under a project.
items should be declared as a whole and should cover all assessment indicators in the corresponding direction of guidance.
project reporting unit recommends a scientific research personnel as the project leader, each topic set up a person in charge, the project leader can serve as the person in charge of one of the topics.
2. The organization and implementation of the project should integrate the advantages of innovation teams in relevant fields throughout the country, focus on research and development issues, strengthen the integration of basic research, common key technology research and development and typical application demonstration tasks, concentrate their efforts and jointly attack.
3. The national key research and development plan project declaration evaluation to take two steps to fill in the pre-declaration, official declaration, the specific workflow is as follows: - the project declaration unit in accordance with the relevant declaration requirements of the Guide, through the National Science and Technology Management Information System to fill out and submit about 3000 words of project pre-declaration, detailing the objectives and indicators of the declared project, a brief description of innovative ideas, technical routes and research basis.
not less than 50 days from the time of publication of the Guide to the deadline for the acceptance of the pre-declaration.
- The project lead declaration unit shall sign a joint declaration agreement with all participating units, and specify the time of signing the agreement; the project lead declaration unit, the project reporting unit, the project leader and the project leader shall sign the letter of good faith commitment, and the project lead reporting unit and all participating units shall implement the requirements of the "Several Opinions on Further Strengthening the Integrity of Scientific Research Construction" and strengthen the examination and control of the declaration materials, eliminate exaggeration and even falsehood.
- each recommendation unit to strengthen the recommended project declaration materials audit and control, on time will be recommended projects through the national science and technology management information system unified reporting.
- professional bodies accept pre-declaration of projects.
to ensure reasonable competitiveness, for the individual guidance direction of non-targeted declaration, if the number of reporting teams is not more than the number of projects to be supported, the guidance direction does not initiate the follow-up project review initiation of the business case, the selection period re-study the release guide.
- professional bodies organize a form of review, and conduct the first round of evaluation according to the status of the declaration.
the first round of review does not require a project leader to reply.
according to the evaluation results of experts, select 3 to 4 times the number of declared items, into the defense evaluation.
for the non-entry defense review of the declaration items, timely feedback on the results of the evaluation of the project reporting unit and the person in charge.
- after receiving the notice of the professional institutions to enter the defense assessment, the declaration unit fills out and submits the official declaration of the project through the National Science and Technology Management Information System.
's official declaration is accepted for 30 days.
- professional bodies to enter the defense review of the project declaration form review, and organize the defense review. the person in charge of the
's declaration project reports the defense via video link.
merit-based projects based on expert reviews.
support only one item in principle for the direction of the guidelines to support 1 to 2 items, such as the evaluation of the first two declared items of the defense evaluation, and the technical route is obviously different, can be supported at the same time, and establish a dynamic adjustment mechanism, combined with process management to carry out the medium-term assessment, based on the evaluation results to determine the follow-up support mode.
. The recommended unit of the organization declaration 1. The Department of Science and Technology of the relevant departments of the State Council; 2. the departments in charge of science and technology of the provinces, autonomous regions, municipalities directly under the central government, cities planned to list separately and the scientific and technological departments of the Xinjiang Production and Construction Corps; 3. The trade associations established by the transformation of the former industrial sector; 4. The strategic alliance for industrial technology innovation in category A shall be included in the pilot scope of the Ministry of Science and Technology and the result of the evaluation as a category A, and the pilot alliance of the innovation and development industry of the science and technology service industry carried out by the Ministry of Science and Technology and the Ministry of Finance.
5. The projects declared by Hong Kong and Macao universities are recommended by the Hong Kong Innovation and Technology Commission and the Macao Science and Technology Development Fund respectively.
each recommended unit shall organize the recommendation within the scope of the unit's functions and business, and shall be responsible for the authenticity of the recommended project, etc.
the relevant departments of the State Council recommend units with which they have a business guidance relationship, trade associations and industrial technology innovation strategic alliances, pilot alliances for innovation and development of science and technology services industries recommend their member units, and provincial science and technology departments recommend units within their administrative divisions. The list of recommended units of the
was publicly released on the public service platform of the National Science and Technology Management Information System.
3. The qualification requirement s.1. The project lead declaration unit and the project participant shall be the research institutes, institutions of higher learning and enterprises registered in the territory of the Chinese mainland (hereinafter referred to as the Mainland units), or the universities of Hong Kong and Macao as determined by the Mainland and Hong Kong, the Mainland and macao Science and Technology Cooperation Committee in consultation (see Annex 1).
mainland units should have independent legal personality, registration time before April 30, 2018, with strong scientific and technological research and development capabilities and conditions, operating management norms.
State organs may not lead or participate in the declaration.
the project lead reporting unit, the project participant steamer and the project team members have good integrity, and there is no record of serious breach of trust in scientific research and the "black list" record of credit in the relevant social field during the disciplinary execution period.
the same project of the declaration unit can only be declared through a single recommendation unit, not long declaration and duplicate declaration.
2. The person in charge of the project (subject) shall have a senior title or doctorate and shall be born after 1 January 1959 and shall spend no less than six months per year on the project.
Hong Kong and Macao declaring personnel should love Hong Kong patriotic, patriotic love of Macao.
3. The person in charge of the project (subject) shall, in principle, be the proposer of the main research idea of the project (subject) and the scientific and technical personnel who actually preside over the research.
public officials of the central and local state organs and the Hong Kong and Macao Special Administrative Region (including other personnel exercising the management functions of science and technology programmes) shall not declare items (subjects).
4. The person in charge of the project (subject) shall be limited to declare 1 project (subject); the National Key Basic Research and Development Plan (973 Plan, including major scientific research plan), the National High-Tech Research and Development Plan (863 Plan), the National Science and Technology Support Plan, the National International Science and Technology Cooperation Special, the National Major Scientific Instrument and Equipment Development Special, the Public Interest Industry Research Special (hereinafter referred to as the "Pre-Reform Plan") and the National Science and Technology Major Special Project,""key research and development projects (including the "Project"
the person in charge of the research project (excluding the task or subject leader) who is the key project of the national key research and development plan, is also not allowed to participate in the declaration project (subject). The total number of projects (topics) under
projects (subjects), project backbone declaration projects and pre-reform plans, major national science and technology projects, and national key research and development plans shall not exceed 2; The research and development plan shall not lead or participate in the declaration of the new national key research and development project in principle after the person in charge of the research project (including the task or subject) and the project backbone withdraw from the project research and development team after the key special project (subject) and withdraw from the project currently undertaken the project (subject).
the planned mandate implementation period (including the post-extension implementation period) is not included in the scope of the study project (including tasks or topics) until 31 December 2019.
5. The specially invited members of the jury shall not declare the project (subject);
6. Foreign scientists employed in mainland units or relevant universities in Hong Kong and Macao, as well as scientists from Hong Kong, Macao and Taiwan regions, may be the principals of key projects (subjects), full-time employed persons shall provide valid materials for full-time employment, and part-time employed persons shall provide valid materials for employment by both units at the same time and shall be submitted together with the paper project pre-declaration.
. After the declaration item is accepted, the reporting unit and the person in charge shall not be changed in principle.
specific declaration requirements for the project, as detailed in the declaration guidelines for the key projects.
each declaration unit may use the public service platform of the National Science and Technology Management Information System to inquire about the research projects undertaken by the relevant scientific research personnel before formally submitting the project declaration, and to avoid duplicate declarations.
. 4. Specific declaration method 1. Online filing.
request each reporting unit to fill in the online through the public service platform of the National Science and Technology Management Information System as required.
project management professional organizations will file the declaration online as the basis for follow-up form review, project evaluation.
pre-declaration format is downloaded in the relevant columns of the National Science and Technology Management Information System Public Service Platform. The processing time for filing a pre-declaration form online by the
project declaration unit is from 8:00 on June 18, 2019 to 16:00 on August 7, 2019.
the declaration items entering the defense review link, the declaration unit shall fill in the formal declaration according to the requirements and submit it through the National Science and Technology Management Information System, with further notice of the specific time and relevant requirements.
National Science and Technology Management Information System Public Service Platform: Technical Consultation Phone: 010-58882999 (Trunk); Technical Advisory Email: program istic.ac.cn.
. 2. Organizational recommendation.
please send the recommendation letter (paper, 2 copies in one form) and the list of recommended items (paper, 2 copies) to the China Institute of Science and Technology Information by August 13, 2019 (whichever is the time of sending).
the list of recommended items must be generated and printed directly through the system (the list of items should be consistent with the recommended items submitted in the information system).
shipping address: Beijing Haidian District Revival Road 15 CITIC 170 room, zip code: 100038.
Contact: 010-58882171.
3. Material submission and business advice.
please request the declaration unit before August 13, 2019 (subject to the time of delivery), will be stamped with the declaration unit's official seal of the project pre-declaration (paper, one type 2 copies), sent to assume the project's key special management of professional institutions.
pre-declaration of the project must be generated and printed directly through the system.
the key special consultation telephone and sending address as follows: (1) "synthetic biology" key special consultation telephone: 010-88225123, 010-88225178.
sending address: Beijing Haidian District, West Fourth Ring Road 16, 4th floor of china biotechnology development center, zip code: 100039.
(2) "Key scientific issues of transformative technology" key special consultation telephone: 010-68104823.
(3) "Developmental programming and its metabolic regulation" key special consultation telephone: 010-68104388.
address: Beijing Haidian District, Sanlihe Road, No. 1 Xiyuan Hotel, No. 9, the Ministry of Science and Technology High-Tech Research and Development Center (Planning and Supervision), zip code: 100044.
Ministry of Science and Technology issued on June 4, 2019 to release synthetic biology is a relatively new research area of synthetic biology is a relatively new field of research that can significantly affect many fields, including biology, nanomanufacturing and medicine.
the main challenge in this emerging field is to embed computing in the molecular environment without being able to insert an electronic microcontroller.
this requires the development of methods that can effectively represent calculations using molecular components.
a team of researchers at the University of Texas at Austin created CRN, a new language for programming certainty (mass) chemical dynamics when performing calculations.
in their paper, published in advance on arXiv, the researchers outlined the new language and built a compiler that turned the CRN program into a chemical reaction.
"A key technical challenge in synthetic biology is to design a chemical controller that interacts in the cellular environment to accomplish a specific task," Marko Vasic, one of the researchers who conducted the study, told Tech Xplore.
" To achieve this, it is necessary to design and program synthetic molecules.
molecules interact through chemical reactions, and by programming molecules, we mean to define the rules of interaction (chemical reactions) between them.
"Recent improvements in DNA synthesis open up exciting new possibilities for molecular engineering."
, however, researchers in synthetic biology first need to design methods to design interaction rules (chemical reactions) to achieve the desired goals.
the main purpose of the study was to design a high-level language that could express chemical reaction behavior in a more intuitive way.
"In software engineering, programmers write in high-level, easy-to-understand languages, and such programs are compiled into machine code that is difficult for humans to understand, but machines understand," Vasic explains.
.
"We tried to establish an analogy in molecular programming by defining a high-level language that is easier to reason about and compiling it into 'complex' chemistry."
"CRN is based on two ideas: modularity and the use of oscillators.
modularity means that the language consists of a set of chemical reactions called modules that can be in different sets of reactions.