Synthetic cannabis reversed depressive behavior in mice
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Last Update: 2021-03-14
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Source: Internet
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Author: User
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The team of Li Xiaoming of Zhejiang University School of Medicine discovered a new neural loop involved in the onset of depression and revealed a new mechanism for the treatment of depression with cannabis, thus deepening the understanding of the pathogenesis of depression and providing new molecular targets for the clinical diagnosis and treatment of depression. The results were published January 15 in the journal Nature Medicine.
Li Xiaoming's team focused on a brain region called the amygdala. The amygdala is located on the edge of the system that controls emotions and is named for its shape that resembles almonds. They found that the amygdala has two neural loops that perceive "pleasure" and "disgust." For the first time, the team identified candidate genes for expression of pleasure and disgust in the amygdala and their associated neural loops at both the genetic and loop levels.
if the synth activity of the neural loop is likened to a high-speed car, the cannabinin-in-the-brain cannabinist is the car's braking system.
Li Xiaoming's team discovered a new neural loop involved in the onset of depression -- gallbladder-systolic-positive neurons in the amygdala projected into the volt-blocking nucleus. Further studies have found that in animal models of depression caused by social stress stress, synactical activity in the loop is significantly enhanced, and the use of photogenetic techniques to inhibit the activity of this neural loop can effectively overcome depressive symptoms.
, they found that cannabinin-specific expressions were found in this loop, and that cannabinin-specific expressions on the loop were significantly reduced in depressed animal models. What's more, they found that exo-synthetic cannabis can reverse depressive behaviors caused by social stress.
the relationship between these cannabinin-highly expressed cannabinomas and depression in the amygdala "disgusting" loop? In the brains of pessimistic mice, the researchers found that the expression levels of his cannabinin receptors were significantly lower than those of the control group and the optimistic mice. Relevant evidence suggests that reduced cannabinin-like expression in the brains of pessimistic mice prevented excessive synactical activity in the amygdala's expression of "disgusting" neural circuits from being effectively inhibited when stressed.
, will medical marijuana be a new dawn for antidepressant treatment? "Actually, there's still a long way to go to treat depression." "However, our study suggests that cannabinin-like ligands can act as molecular markers for depression diagnosis, " Li said. Currently, we have successfully designed and synthesized a clinical PET tracer for cannabinin receptors, and are conducting relevant clinical studies. (Source: Cui Xueqin, China Science Daily)
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