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Systemic lupus erythematosus (SLE) is an autoimmune disease in which the immune system attacks body tissues, causing widespread inflammation and affecting multiple organs, such as the kidneys and brain
.
As we all know, in SLE patients, the gut "microbiome"-all the microorganisms living in the human gut-has changed
A healthy human intestine contains billions of microorganisms that are essential to the normal function of the intestine
.
They can resist pathogens, assist in the metabolism of food, and can also affect the immune response
The team used fecal samples to isolate DNA from the gut microbiome, and then used a next-generation sequencing machine for metagenomic shotgun sequencing
.
This is a technology to sequence all the genes in a complex sample by fragmenting all the genomes, sequencing the short fragments, and then recombining the sequences
The gut microbiota can affect broader body functions by changing the number of small molecules or metabolites that circulate in the liquid part of the blood, that is, the plasma
.
Therefore, the team continues to integrate the gut microbiome data with the data of the entire plasma metabolite (ie, the plasma metabolome)
"Our analysis revealed the interaction between the microbiota and the host mediated by the metabolome," senior author Yukinori Okada explains
.
"A special molecule called acylcarnitine is positively related to sle-related bacteria
Acylcarnitines are known to induce inflammation, so SLE may be seen as a potential trigger for over-activation of the immune system
This study reveals the specific microbial landscape of SLE patients for the first time, helps us understand the relationship between the gut microbiota and SLE, and provides useful resources for future research
Article title
Metagenome-wide association study revealed disease-specific landscape of the gut microbiome of systemic lupus erythematosus in Japanese