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    Home > Active Ingredient News > Drugs Articles > Tablet coating technology and common problems

    Tablet coating technology and common problems

    • Last Update: 2014-12-09
    • Source: Internet
    • Author: User
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    Problems and Countermeasures of tablet coating technology: sticking tablet: it is mainly due to too fast spraying amount, which violates the principle of solvent evaporation balance and makes tablets adhere to each other In this case, the spraying amount of coating liquid should be reduced, the temperature of hot air should be increased, and the speed of the coating pot of the coating machine should be accelerated The "orange peel" film is mainly caused by improper drying and low spray pressure of the coating liquid, resulting in uneven heat concentration of the ejected droplets, resulting in ripple of the film In this case, evaporation rate should be controlled immediately and spray pressure increased "Frost spraying" appears on the coating film: this situation is caused by high humidity of hot air, long spraying process and poor atomization effect At this time, it is necessary to reduce the temperature, shorten the spray range and improve the atomization effect There is color difference between tablets: this situation is caused by the uneven fan surface when spraying liquid, excessive solid content of coating liquid or slow rotation speed of coating machine At this time, the spray angle of the spray gun should be adjusted, the solid content of the coating liquid should be reduced, and the rotating speed of the coating machine should be increased properly There are pinholes on the surface of coating film: this situation is caused by too much air involved in the preparation of coating solution Therefore, too much air should be avoided when dispensing "Bridge construction": refers to the blurring of the mark caused by the coating film on the lettering piece The solution is: slow down the coating spraying speed, reduce the drying temperature, and pay attention to control the hot air temperature Appearance of color spots: this situation is caused by uneven mixing or insufficient fineness of solid characteristics when preparing coating solution The solution is to mix the coating solution well Crack, fracture, peeling or edge wear of the coating film on the surface or edge of the tablet: if the coating liquid-solid content is improperly selected, the rotating speed of the coating machine is too fast, and the spraying amount is too small, the appropriate coating liquid-solid content shall be selected, and the rotating speed and spraying amount shall be properly adjusted; if the hardness of the tablet core is too poor, the formula and process of the tablet core shall be improved.
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