Take car-t as spear, attack HIV shield!

Source: in the era of medicine, 2018-1-3 HIV infected T cells (Credit: NIAID / Flickr), known as chimeric antigen receptor T cells (car-t), have become the target of headlines in 2017, because they may cure some leukemia and lymphoma patients In addition, people's interest in car-t has gone beyond cancer Scientists from UCLA participated in the study to see if car-t can also fight HIV Their technology revolves around CD4, a protein HIV uses to infect cells, on the surface of immune cells Scientists use gene therapy to design hematopoietic stem cells that can carry car The car they developed combines HIV with CD4 to activate other parts of the car and kill HIV The research article "long term persistence and function of forensic stem cell derived Chinese Anti receiver T cells in a nonhuman primary model of HIV / AIDS" was published in the journal PLoS pathogen UCLA's team believes that car-t's approach to HIV treatment will help make up for a major flaw in antiretroviral drugs These treatments often suppress HIV to undetectable levels, but without a full-scale attack by the immune system, the virus cannot be completely eliminated UCLA researchers believe that an effective car-t therapy has the potential to provide lifelong immunity Scott kitchen (source: UCLA) used engineered car modified hematopoietic stem cells to enter the bone marrow and mature into functional circulating immune cells in animal experiments The researchers believe that if it works in the human body, car-t and antiretroviral drugs may be the most effective, or even eliminate the HIV Library - the hidden virus library, otherwise, the virus in it will not respond to antiretroviral drugs Other academic groups are also studying the use of car-t to attack HIV, including the University of Pennsylvania, the original developer of kymriah, the first FDA approved car-t treatment for cancer, at Novartis In October 2017, a study published by the University of Pennsylvania research team showed that their anti HIV car-t prevented the spread of the virus in human cells Car-t suppresses viral levels in mice that no longer take antiretroviral drugs Many other studies of immunoenhancement therapy for AIDS are also underway They include drugs that inhibit PD-1 and other "checkpoints" that prevent the immune system from eliminating pathogens, as well as antibody vaccines and genetic editing techniques CRISPR.