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1. Center Obesity Index and All-Cause Risk Study doi: https://doi.org/10.1136/bmj.m3324 Researchers recently quantified the central obesity index, including waist circumference, hip circumference, thigh circumference, waist-hip ratio, waist-height ratio, waist-to-leg ratio, body obesity index and body type index, through a systematic review and meta-analysis of the study, and the relationship between waist, hip, thigh, waist-hip ratio, waist-height ratio, waist-leg ratio, body obesity index and body type index.
total of 72 forward-looking cohort studies were included in this meta-analysis, which included 2228,297 participants.
study found that the risk of death ratio was 1.11 and 0.90 for every 10 cm (3.94 inches) increase in waist circumference and 0.82 for each additional 5 cm of thigh circumference, and 1.20, 1.24 and 1.21 for each additional 0.20, 1.24 and 1.21 per lumbar-to-leg ratio.
risk ratio of 1.17 for every 10% increase in body obesity index and 1.15 for every 0.005 unit increase in body mass index.
results were significantly maintained after adjusting for body mass index.
Researchers found an approximate J-type association between waist circumference and waist-height ratio and all-cause mortality in both men and women, a monotonous positive correlation between waist-to-hip ratio and body mass index and all-cause mortality, and a U-shaped correlation between body obesity index and all-cause mortality.
: https://doi.org/10.1136/bmj.m3320 Recently researchers examined the clinical manifestations, risk factors, and maternal and perinatal outcomes of pregnant women with suspected or confirmed coronavirus disease (covid-19).
this systematic review and meta-analysis study included 77 cohort studies in which 11,432 pregnant women were diagnosed with suspected or confirmed covid-19 patients.
most common clinical manifestations of covid-19 during pregnancy were fever (40%) and cough (39%).
Compared to non-pregnant women of childbearing age, pregnant women with covid-19 have a lower risk of developing fever symptoms (ratio 0.43) and myalgia (0.48), but are at increased risk of intensive care (1.62) and invasive aeration (1.88).
73 pregnant women (0.1 per cent) who were diagnosed with covid-19 died.
age increase (1.78), high body mass index (2.38), chronic hypertension (2.0) and diabetes (2.51) were associated with severe covid-19 pregnancy.
and past co-diseases are risk factors for intensive care (4.21) and invasive aeration (4.48).
rate of 6 per cent for Covid-19 mothers.
women with covid-19 had a higher risk of precocity (3.01) than those who did not have covid-19.
a quarter of newborns with covid-19 received NICU care (25%), the risk of hospitalization (risk ratio 3.13) increased significantly.
SGLT2 inhibitors reduce the risk of cardiovascular events in patients with type 2 diabetes Doi: https://doi.org/10.1136/bmj.m3342 Researchers recently examined the effects of sodium glucose cotranserative protein 2 (SGLT2) inhibitors and lipid-peptidease-4 (DPP-4) inhibitors on cardiovascular event risk in patients with type II diabetes.
compared to DPP-4 inhibitor users, SGLT2 inhibitors used MACE (incidence per 1000 people-years: 11.4 v 16.5; risk ratio 0.76), myocardial infarction (5.1 vs 6.4; 0. 82), reduced risk of cardiovascular death (3.9 vs. 7.7; 0.60), heart failure (3.1 vs. 7.7; 0.43) and all-cause death (8.7 vs. 17.3; 0.60).
SGLT2 inhibitors had no significant effect on the reduced risk of ischemic stroke in diabetic patients (2.6 v 3.5; 0.85).
similar effects on MACE for Kaglia Net (0.79), Dagly Net (0.73) and Ipale Net (0.77).
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