Tamoxifen may inhibit the development of myotube diseases

Myotubular myopathy is a serious hereditary disease Since birth, all the skeletal muscles of the patients have been weakened, showing facial paralysis, blepharoptosis and muscle weakness of limbs The incidence rate of the disease is 1/50000, of which 90% of the affected infants are less than two years old Tamoxifen is a drug approved by FDA (http:// for the treatment of breast cancer (http:// Recently, researchers from the University of Geneva and the University of Strasbourg in France found that tamoxifen has greatly inhibited the development of a serious genetic disease, myotube disease In addition, animal model study also showed that the life expectancy of mice after treatment with the drug increased by 7 times! In view of the fact that clinical trials (http:// are far from effective, scientists at unige began to turn to a molecule that has been authorized for other human therapies in order to find a faster way to combat this deadly disease Curiously, researchers focused on tamoxifen, a drug used to treat breast cancer, because the molecule has several interesting properties that protect muscle fibers: antioxidation, anti fibrosis and mitochondrial protection