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    Home > Biochemistry News > Biotechnology News > Targeting mitochondria is expected to treat obesity

    Targeting mitochondria is expected to treat obesity

    • Last Update: 2021-08-28
    • Source: Internet
    • Author: User
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    Scientists at the University of California, Irvine have discovered a new pharmacological approach that can reduce mitochondrial dysfunction that leads to diet-induced obesity


    A high-fat diet can lead to obesity and metabolic disorders such as diabetes and fatty liver


    Mitochondria play a vital role in the energy production of cells, and they also coordinate the cell's stress response


    Exquisite genetic studies in mice have shown that keeping the mitochondrial network in a fusion state can overcome obesity caused by a high-fat diet


    In their new research, Professor Edinger and her team used their patented water-soluble, oral bioavailability, synthetic sphingolipid SH-BC-893 to inhibit the endolysosomal transport protein required for mitochondrial fission


    "The imbalance of leptin and adiponectin hormones that accompanies obesity has brought a difficult battle for people who want to lose weight


    The results of this study indicate that SH-BC-893 may be a promising treatment for diet-induced obesity


    Professor Edinger said: "This compound works through a new mode of action-if it is safe and effective for humans, it will provide a new weight loss strategy and can also be combined with other treatments


    DOI 10.


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