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A team at Kyusju University in Japan has discovered a protein called DOCK1, a protein that plays an important role in cancer cell survival and metastasis, and a compound called TBOPP, which prevents it from continuing to function.
Previously, it has been learned that the proliferation and metastasis of cancer cells with mutated genes is due to changes in cell morphology caused by the "RAC" molecular life, and it is difficult to develop drugs that directly control RAC, so researchers are looking at the molecules that make RAC active.
Japanese team found a protein called DOCK1 among a number of RAC-related molecules.
they genetically prevented the DOCK1 protein from being expressed, they found that the cancer cells' immersion into surrounding tissue and the absorption of nutrients from outside the cells slowed and the cancer cells' viability declined.
team determined that DOCK1 plays a key role in the resification of RAC molecules.
In order to inhibit RAC's activity, they screened out about 200,000 compounds from "TBOPP" compounds that blocked DOCK1 activity and used them in mice that transplanted cancer cells, only to find that both the metastasis of cancer cells and tumor enlargement were inhibited, and no significant side effects were found.
team believes the compound could be used to treat incurable cancers with mutated genes and will accelerate the development of safe and effective anti-cancer drugs through repeated validation.
the study was published in the American scientific journal CELL REPORTS.
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