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    Home > Active Ingredient News > Drugs Articles > Technical requirements of pelletizer for Pelletizing Properties

    Technical requirements of pelletizer for Pelletizing Properties

    • Last Update: 2018-12-06
    • Source: Internet
    • Author: User
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    The dry granulator is a completely closed dry granulator system, which can reduce all kinds of pollution in the production process, thus reducing the risk of health problems The equipment can choose different angle granulators according to the different properties of the materials of the customers In the process of granulating, the smooth discharging is ensured, and the phenomenon that the materials will not turn up, roll or follow in the process of granulating is solved The production of various types of feed particles depends on the safe operation of the dry pelletizer The formation of particles depends on two aspects: on the one hand, it depends on the effective utilization and transmission of external forces; on the other hand, it depends on the physical properties of particles But it is inevitable that there will be a series of problems in the use of dry granulation: 1 In the process of dry granulation, if the pressure of the pressing roller is too high, the pressed particles will be too hard, which will reduce the compressibility of the particles In the next tablet pressing, it needs a large pressure to press, or the hardness of the prepared tablets is small; when some particles are too hard, it is easy to produce flake phenomenon When the dry particles are too hard, they are difficult to dissolve in water and affect the disintegration of particles 2 The roundness of particles is low, which directly affects the fluidity of particles The roundness of dry granulation particles is slightly worse than that of wet granulation particles, but the roundness of particles can be controlled by adjusting the tablet thickness of dry granulation machine and the structure of finishing machine 3 After pelletizing, there are still more fine particles and poor compressibility of materials Replace materials with good compressibility, such as microcrystalline cellulose, less pre gelatinized starch adhesive, and increase the amount of adhesive; the pressure of the press roll is small, the tablet is fragile, and the pressure or feeding speed of the press roll is increased 4 The amount of lubricant in the material of material pressure roller is less, so the content of lubricant should be increased However, the total amount of lubricant should be paid attention to On the premise of improving or solving the problem of material pressure roller, the amount of lubricant that can be added less is added less There are hygroscopic materials in the materials, which will also cause the phenomenon of material sticking and pressing roller 5 In the process of granulation, the feeding is not continuous, resulting in the discontinuity of the extruded sheet The fluidity of the raw and auxiliary materials is too poor after mixing Replace the materials with good fluidity or add flow aids to the materials In the way of multiple granulation (note that some materials such as microcrystalline cellulose are not suitable for repeated granulation), the materials or some materials should be granulating first to increase the fluidity of materials.
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