Ten-year quest to discover second 'short sleep' gene

Over time, various diseases caused by lack of sleep have been found, such as decreased thinking ability, impaired alertness and judgment, immune dysfunction, loss of balance in the body, and so onOur physical and mental health is compromisedIs there a way to get us to sleep in a short time? A recent paper published in the journal Neuron gives us the answer to the "gene"! Turns out, some people can really sleep only 4-6 hours can be full of blood resurrection!:the first short sleep gene: the discovery of DEC2
DOI: 10.1126/science.1174443as early as 2009, DrYing-Hui Fu, a professor of neuroscience at the Weir Institute at the University of California, San Francisco, and a pair of "short-sleep" mothers and daughters of the team discovered a gene called DEC2 mutationIt is because of this mutation in this gene that it can be full of blood and vitality just after about six hours of sleep each nightThat's less than many experts recommend for adults to sleep at least seven hoursstudy found that this is the first time that the existence of "natural short sleep" has been interpreted in the genetic field, and that the DEC2-encoded protein works by regulating the expression of other genes, including the genes that regulate the hormone orexin, which regulates awakeningAlthough the gene is hereditary in some cases, it does not explain all short sleep conditions because of its rare mutation rateSo, in order to further understand the magic of "short sleep", DrFu and his team after 10 years of scientific research, and finally have a new discovery's latest findings: ADRB1 gene mutation "short sleep"Picture Source: References
After a decade of exploration, researchers found in a family member with three generations of genetic "short sleep": No one carries the DEC2 mutation! So what other genes are influencing "short sleep"? , the researchers used genetic sequencing and genetic chain analysis techniques to determine the exact chromosomal location of mutations associated with specific traits to comb the family's genome The study found that a gene mutation called ADRB1, like the DEC2 mutation, is closely related to natural short-lived sleep since then, the second "natural short sleep gene" has been found! So how does this new genetic mutation act on short sleep? Photo Source: References
Researchers found in a group of mice genetically engineered to have the same ADRB1 mutation as humans: The ADRB1 gene is responsible for encoding epinephrine-beta receptors, which cause receptor stability to decrease and function affected After the ADRB1 gene mutation, the mice lost 55 minutes of sleep and woke up immediately after light stimulation crack the health threat of sleep deprivation
"Today, most people don't get enough sleep for a long time, " says Dr Ying-Hui Fu If you need eight to nine hours of sleep, but only seven hours, your sleep won't meet your body's needs Over time, you will be more likely to develop cardiovascular disease, cancer, dementia, metabolic problems, and become less immune And people with the 'short sleep' gene, even if they sleep less than seven hours, do not suffer any adverse health effects caused by lack of sleep Further research continues to find that these short sleepers tend to be more optimistic, more energetic, and have better multitasking skills Some researchers even think they may live longer The exact cause of these benefits is still unknown, but Dr Louis Pt?ek, a professor in the Department of Neurology at the Weir Institute for Neuroscience at the University of California, San Francisco (UCSF), says the findings are an important beginning to understand the relationship between good sleep and overall health Further exploration of the mechanism of beta 1-AR may be a potential drug target for sleep-related conditions that can alleviate the suffering of insomniacs the conclusion spend a third of your life on sleep, sleep ingesting physical and mental fatigue, and make people happier and healthier So, even if we don't have such an "excellent" gene, but also have to sleep well, sleep full Oh! References: A Rare Mutation of Beta 1-Adrener Affect Ssleep/Wake Behaviors 2 After 10-Year Search, Scientists Find 'Short' Gene