TET3-mediated de-methylation plays an important role in THER-dependent DNA damage repair.

On March 21, EMBO Reports published a research paper by Li Jiali of the Kunming Institute of Zoology of the Chinese Academy of Sciences, which revealed the regulatory role between DNA de-methylation and DNA damage repair.
, an assistant researcher at Kunming Animal Institute, was the first author of the article, and Li Jiali, a researcher, was the first author of the communication.
Accurate and effective DNA damage and repair responses are important for maintaining genomic integrity in all types of cells in the body, and obstacles to DNA damage repair can cause serious diseases, including a variety of cancers, immunodeficiency, metabolic disorders, blood system diseases, aging, and neurological disorders.
DNA methylation and de-methylation is one of the important pre-methylation regulations, which play an important role in gene transcription, growth and development, and disease process;
ATM-telangiectasia and ATR (ATM and Rad51 related) protein kinases are important core regulatory factors in DNA injury response.
Previous studies by Li Jiali's team have found an important relationship between the loss of specific 5hmC and the production and degenerative lesions of neurodegenerative disease cerum cogeneration, as well as degenerative lesions, and revealed that TET1 is involved in the DNA repair process of ATM kinase dependence.
, the researchers further discovered that the DNA damage response response of UV and Camptothecin-induced ATR dependence directly led to an increase in the DNA demethylation intermediate 5hmC mediated by TET3 enzymes; It is confirmed that in the process of DNA injury response on ATR dependence, ATR increases its stability and 5hmC production activity by phosphate TET3, thus promoting the repair of DNA damage;
this study reveals for the first time the important role of TET3-mediated dna damage repair in ATR-dependent DNA damage repair, providing new insights into the body's regulatory mechanisms for maintaining genomic integrity and DNA damage repair.
the research project has been funded by the Chinese Academy of Sciences' 100-person program and the National Natural Science Foundation.
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