The 10th National Organic Chemistry Academic Conference was held successfully with the largest number of participants in history

From December 19 to 21, 2017, the 10th National Organic Chemistry Academic Conference of China Chemical Society was held in Shenzhen Convention and Exhibition Center The conference was sponsored by the Chinese Chemical Society and the National Natural Science Foundation of China, organized by the South University of science and technology, and co organized by Shenzhen grabs Institute, Shenzhen Graduate School of Peking University, Shenzhen Graduate School of Tsinghua University, Shenzhen Association of science and technology, and academician activity base of Shenzhen Chinese Academy of Sciences 19 academicians of the Chinese Academy of Sciences (including foreign academicians), more than 80 winners of the "Thousand Talents Program", Changjiang distinguished professor, winners of the National Science Fund for Distinguished Young Scholars, more than 60 winners of the "Thousand Talents Program for young scholars", winners of the "excellent youth fund" and nearly 3000 relevant representatives attended the meeting, with the largest number of participants in history The National Conference on organic chemistry is held every two years This session takes "organic chemistry: new challenges and opportunities" as the theme, fully displays the new achievements of organic chemistry and related research fields in recent two years, discusses the new ideas, new fields and new trends of the future development of organic chemistry, and provides an advanced platform for organic chemists to jointly discuss the latest academic ideas and exchange academic progress in organic field In addition to 15 conference reports, the conference also set up 6 branch meetings in 10 directions, with 135 branch invitation reports and 94 oral reports A total of 850 conference papers were received and 325 wall newspapers were displayed Academic scale is unprecedented Chen Jinpei, report expert of the 10th National Conference of organic chemistry, Chinese chemical society, basic molecular science center of Tsinghua University Academician of the Chinese Academy of Sciences (2001), academician of the Third World Academy of Sciences (2001), director of the center for basic molecular science of Tsinghua University (2012 present) He graduated from Tianjin Normal University in 1975, obtained a master's degree from Nankai University in 1981 and a doctor's degree from Northwestern University in 1987 He worked in Nankai University in 1988 (vice president from 1995 to 2000), and vice minister of the Ministry of science and technology from 2000 to 2008 He is currently a member of the Standing Committee of the National People's Congress, vice chairman of the education, science, culture and Health Committee, vice chairman of the Zhigong Party Central Committee, member of the National Education Advisory Committee, member of the national science and Technology Award Committee, and vice chairman of the European and American students' Association He is mainly engaged in the research of physical organic chemistry He has made systematic and innovative efforts in the methodology and experimental determination of various chemical bond energies in organic solvents, the theory of free radical stability, the thermodynamic driving force and mechanism of no transfer, the reaction mechanism of NADH coenzyme model, the thermodynamics of negative hydrogen, the unified scale of yelide stability and asymmetric organic synthesis catalyzed by organic small molecules Sex work Report title: brief introduction to the establishment and application of bond energy sequence in all ionic media: the essence of organic reaction is the process of forming new organic compounds through the breaking and recombination of chemical bonds Therefore, bond energy is the most significant thermodynamic intrinsic parameter for the occurrence and how of this process Previous studies were mainly based on the analysis and induction of chemical phenomena in gaseous and molecular solvents However, the research on the understanding and prediction of chemical phenomena in all ionic media by bond energy parameter analysis was backward, which restricted the development of ionic liquid chemistry In recent years, Cheng Jinpei's research group has been continuously carrying out the research on the pKa scale of R-H bond cleavage free energy in ionic liquids Taking the specific application of bond energy in revealing the internal essence of some unexpected "ionic liquid effect" as an example, it shows the powerful function of bond energy research in promoting the development of chemical rationality of ionic liquids Report expert: Feng Xiaoming, School of chemistry, Sichuan University In 1985 and 1988, he received his bachelor's degree and master's degree from the school of chemistry, Lanzhou University; in 1996, he received his doctor's degree from the Institute of chemistry, Chinese Academy of Sciences; in 1998, he went to the Department of chemistry, Colorado State University in the United States to do postdoctoral research; in 2000, he returned to the school of chemistry, Sichuan University for teaching and doctoral supervisor; in 2013, he was elected as academician of the Chinese Academy of Sciences The research group is mainly engaged in the design and synthesis of new chiral catalysts, asymmetric catalytic reactions, efficient and highly selective synthesis of chiral drugs and physiologically active compounds Report title: a brief introduction of the Research Report on the asymmetric reaction of bimetallic synergetic catalysis with the participation of chiral diazoxide: bimetallic synergetic catalysis and organic small molecule / metal synergetic catalysis are new strategies for the study of asymmetric catalysis, greatly expanding the application scope of metal and small molecule catalysis Feng Xiaoming's research group has designed and developed a class of bifunctional nitrogen oxygen ligands with C2 symmetry for bimetallic catalysis Based on the difference of coordination ability between hard and soft metal salts and chiral diazoxide compounds, Au (Ⅰ) diazoxide Ni (Ⅱ) bimetallic relay catalysis system was developed to realize direct Claisen rearrangement reaction and anti electron demand heteroda reaction By using the compatibility of diazoxide with various metal ions, the cross oxidation coupling reaction between tetrahydroisoquinoline and alkyne with air oxygen was realized Report expert: Tang Yong, Shanghai Institute of organic chemistry, Chinese Academy of Sciences Academician of Chinese Academy of Sciences and deputy director of Shanghai Institute of organic chemistry Mainly engaged in the research of organometallic chemistry, the research group has designed and synthesized a series of new catalysts by using the side arm strategy, which have been successfully applied to asymmetric catalysis, ylide chemistry and high-performance polyolefin synthesis More than 130 papers have been published, more than 20 patents have been authorized (2 PCT patents), and some patents of polyolefin catalysts have been successfully transformed and industrialized He has successively presided over key projects of NSFC, fund for Distinguished Young Scholars, innovation groups, 863 project of Ministry of science and technology and major projects of CAS Report title: a brief introduction to the new reaction research and application report based on alkylmalonate: alkylmalonate is a kind of organic "synthons" with low price, high reaction activity and high atom economy, which has attracted the attention of organic synthesis chemists in recent years Tang Yong's group developed a new method of stereoselective construction of two kinds of polycyclic indoline skeletons by series cyclization By using this method, the synthesis of differential isomer (±) - 11-demethoxy-epi-mytoidine, the total synthesis of natural product (±) - akuammicine and the formal synthesis of (±) - strychnine of Malagasy alkaloid were completed, and indole and bisection were realized A new method for the construction of chiral hexahydrocarbazole compounds with high efficiency and high stereoselectivity has been developed Report expert: Wang Rui, School of basic medicine, Lanzhou University, Gansu Province Key Laboratory for preclinical research of new drugs In 1978, he was admitted to Lanzhou University In 1988, he received his doctor's degree (jointly cultivated by Lanzhou University and Kyoto University in Japan) He was a postdoctoral student of Lanzhou University and Kansas University in the United States Special professor of "Yangtze River Scholar" of the Ministry of education, winner of the National Science Fund for Distinguished Young Scholars, and leader of the national "ten thousand talents plan" of the Central Organization Department, is responsible for the innovation team of the Ministry of education of "peptide medicine" and the key technology topics of the national major science and technology special peptide of the 11th and 12th Five Year Plan of the Ministry of science and technology of the people's Republic of China Among the 321 SCI papers published by corresponding authors, 113 are in zone 1, 22 are in zone 1, the highest impact factor of a single paper is 50.95, the paper has been cited for more than 10000 times, and the h-index index index is 50 They have been selected as "China's highly cited scholars" for three consecutive years It has been granted 35 national invention patents, pct4 international patents, a number of technologies for peptide new drug development and production, and won the Chinese patent award Report title: Based on the introduction of preclinical research report of peptide 1.1 analgesic candidate new drugs: Classic opioids play an important role in the treatment of severe pain, however, due to its many side effects, it hinders the clinical application of such drugs, so it is particularly important to develop new analgesic drugs with unique mechanism of action Peptide drugs have the characteristics of high biological activity, small dosage and obvious advantages in industrial development, which have become a global hotspot in new drug research and development However, the problems such as poor enzyme stability, short half-life in vivo and difficult to penetrate tissue barrier hinder its clinical application Wang Rui's research group took endogenous opioid peptide as the template, modified it with a variety of non natural amino acid blocks, and comprehensively adopted the modification strategies such as peptide chimerism, synthesized and screened a series of new candidate drugs with significantly longer half-life, which can also play a strong analgesic effect in the central nervous system through the blood-brain barrier Through the molecular mechanism study, it is found that these candidate drugs selectively activate the G protein signal pathway system after binding to the receptor, but the activation of β - arrestin2 signal pathway is weak, which indicates that these compounds are not easy to produce toxic side effects Report expert: Lei Aiwen, School of chemistry and Molecular Science & Institute of higher learning, Wuhan University From 1991 to 1995, Huaibei Normal University studied for bachelor's degree; from 1995 to 2000, Shanghai Institute of organic chemistry, Chinese Academy of Sciences studied for doctor (Tutor: academician Lu Xiyan); from 2000 to 2003, University of Pennsylvania postdoctoral; from 2003 to 2005, Stanford University postdoctoral; in 2010, won the National Fund for Distinguished Young Scholars; in 2013, served as Wuhan University Higher Education Vice president of the Research Institute; in 2014, Professor of Yangtze River scholars of Wuhan University; in 2015, researcher of FRSC of Royal Society of chemistry To explore new and efficient bonding methods has always been the research direction of our research group Using a variety of nucleophiles to construct materials from two nucleophiles, including direct use of benzene, tetrahydrofuran, cyclohexane and other C-H compounds, to realize the efficient and selective construction of C-C and C-X bonds Report title: oxidation induced C-H activation and oxidative coupling report brief introduction: breaking the coupling reaction between traditional electrophilic (E) / nucleophilic (nu), the research team developed a new bonding strategy - "oxidative cross coupling" by using Nu 1 / nu 2 To achieve green chemistry in organic synthesis, the team developed four generations of oxidative coupling reactions After studying the oxidative cross coupling reaction of r1m1 / r2m2 and r1m / r2-h, two kinds of direct coupling reactions of different r-hs under oxidation conditions were established, which avoided the use of chemical equivalent organometallic reagents as nucleophiles In addition, this kind of coupling reaction can be completed by two different r-hs through photochemical and electrochemical processes without additional oxidants In addition, in-depth understanding of such reactions is also the focus of the research group The mechanism of these reactions can be revealed by XAS, IR, Raman, EPR and NMR spectra Reporting expert: Li guigen, Institute of chemistry and biomedical sciences, School of chemistry and chemical engineering, Nanjing University Bachelor of Jiangsu Normal University (1984), master of Nankai University (1987), assistant professor of Chemistry Department of Nanjing University from 1987 to 1990 He received his Ph.D from the University of Arizona in 1995 From 1995 to 1997, he played a key role in the research of 2001 Nobel Prize in chemistry by Professor K Barry Sharpless In 1997, he successively served as assistant professor / Associate Professor / Professor / Professor of the highest honor (Paul Whitfield horn Professor) of Texas Institute of technology National Fund for Distinguished Young Scholars (Overseas), special professor of the national "thousand talents plan" in 2011, winner of Jiangsu Province's "entrepreneurship and innovation plan" and Nanjing city's "321 plan" The research group is mainly engaged in asymmetric synthesis chemistry and metal catalytic reaction, and has published more than 300 papers