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    Home > Active Ingredient News > Immunology News > The ability to resist new coronavirus infection prompts a new vaccine target "Nature" paper

    The ability to resist new coronavirus infection prompts a new vaccine target "Nature" paper

    • Last Update: 2021-12-08
    • Source: Internet
    • Author: User
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    A study published by "Nature" Pre-existing polymerase-specific T cells expand in abortive seronegative SARS-CoV-2 pointed out that past exposure to other coronaviruses may increase the body's speed of clearing the new coronavirus (SARS-CoV-2) , Because the immune system can remember viral replication proteins that are highly conserved among different coronaviruses
    .

    The study analyzed medical staff with a higher risk of exposure to SARS-CoV-2.
    Although these people had negative SARS-CoV-2 infection or antibody test results, there were signs that they were sensitive to the memory T cells of this conservative complex.
    The response has increased, suggesting that they can quickly clear SARS-CoV-2
    .

    The results of the study suggest that this highly conserved protein can be used as a target for future vaccines against endemic and new coronaviruses
    .

    SARS-CoV-2 is highly contagious, and some individuals at higher risk of exposure to it will be negative in standard diagnostic tests
    .

    Previous studies have shown that exposure to coronavirus can produce memory T cells, which may be effective in attenuating SARS-CoV-2 infection
    .

    Mala Maini of University College London and colleagues hypothesized that since the previously existing memory T cells can recognize the protein of this replication-transcription complex (RTC, a conserved structure involved in viral replication), then these previously existing memory T cells Cells may help quickly control SARS-CoV-2
    .

    The author believes that simulating the expansion of these cross-reactive T cells in vaccine design may be used to prevent various endemic or emerging coronaviruses.

    .

    The author studied 58 medical staff in various hospitals in London, England
    .

    In the first wave of the British epidemic, although these individuals were at high risk of exposure, no one tested positive for SARS-CoV-2 infection
    .

    The authors compared the T cell response of this cohort with medical staff in the control group who were laboratory-confirmed with SARS-CoV-2 infection
    .

    Compared to individuals who test positive, individuals who can escape infection appear to have a stronger T cell response, especially for this kind of RTC
    .

    The new crown-specific T cells tested negative in the serum of medical staff
    .

    Source: Maini et al.
    ©NatureNature | doi: 10.
    1038/s41586-021-04186-8
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