The activity of HIF protein in immune cells is associated with the intensity of inflammatory response.

Inflammatory responses also require a supply of energy, and one of the most important sources of energy is oxygen.
we all know that oxygen is important for the normal functioning of the immune system.
in fact, oxygen is not only the key to cell survival, but also helps with the occurrence of inflammatory responses.
recent researchers from erlangen-Nuremberg University found that the body can save oxygen consumption by misleading immune cells into thinking they lack oxygen supplies, which can eventually lead to a decrease in the intensity of the inflammatory response.
results were published in the latest issue of communications nature.
the oxygen receptors inside the body sense the amount of oxygen in the cells, which are activated back when oxygen levels are low, and one of the most important receptors is HIF (hypoxia-inducente factor).
Professor Aline Bozec et al. found that the increase in protein activity in immune cells was accompanied by a decrease in the intensity of the inflammatory response.
findings provide a theoretical basis for the treatment of inflammatory reactive diseases such as rheumatism, multiple sclerosis, and so on.
"HIF acts as a 'psychotherapist' in specific immune cells, such as B cells," the authors explain.
under the influence of HIF, B cells are able to begin to secrete immunosuppressive factor IL-10, thereby suppressing the intensity of the inflammatory response.
Bozecjiaoshou by shutting down the activity of HIF in B cells, it is found that this operation prevents the end of the inflammatory response, leading to the onset of chronic inflammatory diseases.
results offer new hope for targeting HIF activity to treat a variety of chronic inflammatory diseases such as rheumatism, multiple sclerosis, and so on.
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