The addition reaction of N-bromide diamide (NBS).

related topics .N-bromide diamide (Acronym NBS) is an important
reagent
the synthesis of
organic
. It is widely used in free-form replacement reactions and pro-electric addition reactions. NBS can be considered a substitute for bromine.reaction to olefinsNBS can react with olefin 1 in an aqueous solution to produce hydroxybromodane2. The condition of the reaction optimization is to dissolve the olefins in any 50% aqueous solution of metformin, metformin, tethydrofuran and sbutanol at 0 degrees C, and add NBS to the division. The reaction is based on: i) the generationbromine ions; ii) the pro-nuclear attack of water molecules. Stereo selectivity is a product of trans-addition, which conforms to the Mars rule..By-products of this reaction include α-bromide and
compounds
. The production of these by-products can be reduced with newly recrystrysed purified NBS.if water is not added and other pro-nuclear reagents are added, other bi-hydrative group compounds can also be synthesized.. Bromine N-bromide amberamide in hoffmann re-discharge reactions can be converted into isocyanate, an intermediate product, by Hoffman's re-discharge reaction in the presence of strong alkalis (e.g. DBU). Isocyanate reacts with hydroxy compounds such as methanol to produce hydrolytic and isolated amino acids..