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    Home > Biochemistry News > Biotechnology News > The advantages of hydrogen are seen from the limitations of hydrogen sulfide in biomedical research.

    The advantages of hydrogen are seen from the limitations of hydrogen sulfide in biomedical research.

    • Last Update: 2020-09-14
    • Source: Internet
    • Author: User
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    In the field of basic biomedical research, there have been many biomists that have excited medical scientists because they have been found to play a role in a variety of diseases and injuries.
    , however, these molecules often do not meet the expectations of the beginning.
    because of the complexity of biometric networks, any molecule that has important physiological functions is not the same thing as converting them into drugs or drug targets.
    Science recently reviewed star molecules such as hydrogen sulfide, leptin, hunger, nitric oxide, and acetylase and found that they did spawn some drugs, but did not start to look so good, and certainly not that research on these molecules failed.
    as Mark Roth, founder of Icaria, says, hydrogen sulfide research never ends, and the company's decision in 2011 to abandon its investment in hydrogen sulfide was a commercial decision, not an academic conclusion.
    these powerful molecules have not proved useless.
    , a vascular biologist at the University of Pittsburgh, says basic research often takes 10 to 20 years to have an impact on everyday life.
    , the world's largest star molecule, is a highly toxic substance with a special smell of rotten eggs, which is also released by volcanic eruptions.
    a large number of academic research and scientific and technological news media, the highly toxic molecule hydrogen sulfide has been found to have a variety of biological effects.
    have high hopes from scholars and journalists to tackle the obesity, heart failure, muscle building and even help us travel into space.
    scientists' findings have also spawned the creation of biopharmaceutical companies that specialize in hydrogen sulfide-based therapeutic drugs, notable for the Icaria company founded in 2005, but which announced in 2011 that it would abandon its commitment to the field.
    , from blind optimism to pessimism 10 years ago, the biological study of hydrogen sulfide is like day in and day out.
    gas was found to be the third gas signaling molecule in the body, with a variety of biological effects and potential disease treatment effects.
    hydrogen sulfide includes relieving inflammation, fighting active molecules, and lowering blood pressure.
    roth and others have found that hydrogen sulfide induces mice to go into hibernation, and once normal breathing air is restored, animals can return to normal hibernation.
    findings have attracted the attention of many scholars and the media, hoping that the effect could be used for trauma and war injury treatment, and even for the induction of hibernation of crew members during long-term travel in space.
    these ideas quickly encountered setbacks, as repeated experiments using large animals such as pigs and sheep found that hydrogen sulfide did not have the same effect.
    Szabo, chief scientist at the University of Texas, said it did not appear to be expected to induce astronauts to hibernate with hydrogen sulfide.
    technical obstacles to the study of hydrogen sulfide.
    , it is not possible to accurately measure the concentration of hydrogen sulfide in cells, which makes it difficult to track and analyze the effects of hydrogen sulfide.
    , because hydrogen sulfide is very toxic, the effective dose and the toxic dose are very close, which results in a very small dose treatment window.
    Roth therefore reduced the study of hydrogen sulfide.
    Szabo also believes that early knowledge of hydrogen sulfide was incomplete, leading some to be overly optimistic.
    the comparative advantages of hydrogen research compared with hydrogen sulfide, hydrogen research has no such problems at all.
    first hydrogen safety is huge, its therapeutic dose window is very wide, as long as effective, do not consider toxic, this is also one of the great advantages of hydrogen.
    addition, hydrogen concentration analysis is easier and more accurate than hydrogen sulfide, on the one hand, hydrogen is relatively stable, not easy to occur chemical reactions, hydrogen in the energy research has accumulated research techniques in this regard.
    hydrogen sulfide is not present in hydrogen studies.
    although there is no depth or scale of hydrogen sulfide research, hydrogen sulfide has since identified some target molecules, such as ATP-sensitive potassium channels.
    although there are no successful drugs, many drugs have entered the standardized clinical research system.
    , hydrogen sulfide drug research is still promising Although hydrogen sulfide research encountered many difficulties, hydrogen sulfide release molecular drugs have been conducted clinical trials.
    nonsteroidal anti-inflammatory compound developed by Antibes Therapeutics in Toronto, Canada, to release hydrogen sulfide.
    nonsteroidal anti-inflammatory drugs commonly used in the clinic can easily lead to side effects such as the appearance of the digestive tract.
    Wallace, founder of Antebe Therapeutics, said they hope hydrogen sulfide release molecules will avoid these side effects.
    nonsteroidal anti-inflammatory drugs with no digestive tract side effects have great market potential.
    the company announced the results of a Phase II clinical trial in August that could treat knee arthritis.
    another hydrogen sulfide-releasing molecular compound, was studied by David Lefer, a cardiovascular physiologist at Louisiana State University School of Medicine.
    the first phase of clinical trials in healthy volunteers and patients with low levels of hydrogen sulfide in the blood showed that the drug increased levels of hydrogen sulfide in the blood and could be protected.
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