The affiliated Renji Hospital found that felodipine can prevent and treat bone and joint postoperative implant infections. Classic antihypertensive drugs may become...

Recently, Yue Bing’s research group, chief physician of the Department of Orthopedics and Joint Surgery, Renji Hospital, Shanghai Jiaotong University School of Medicine, published online in the internationally renowned academic journal “Bioactive Materials” about using the clinically classic antihypertensive drug felodipine to effectively solve the problem.

In recent years, with the increasing aging of the population and the widespread use of medical implants, infections around joint prostheses have become one of the "catastrophic" complications after orthopedic surgery, and the related biofilm formation on the prosthesis surface It is the most difficult problem

In this research, Yue Bing's research group is committed to exploring the prevention and removal of drug-resistant bacteria biofilm on the surface of joint prostheses

The research team further studied the molecular mechanism and found that felodipine can inhibit the expression of aminoglycoside antibiotic modifying genes (aacA-aphD), thereby enhancing the antibacterial efficacy of antibiotics such as gentamicin, and by overactivating the hydrolytic activity of ClpP protease Destroy the normal structure of bacteria

The proposed regimen of felodipine combined with gentamicin will have broad clinical application prospects in the prevention and elimination of biofilm infections of drug-resistant bacteria in joint prostheses, allowing traditional antibiotics to continue to play a role in the prevention and treatment of postoperative infections An important effect, effectively reducing the number of surgical debridements caused by infection, reducing the degree of dependence on "special use grade" antibiotics, and effectively reducing the pain and economic burden of patients

Dr.