The Amplification Refractory Mutation System
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Last Update: 2021-03-06
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Source: Internet
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Author: User
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The amplification refractory mutation system (ARMS) is a simple and rapid method of detecting point mutations, restriction fragment length polymorphisms, and small deletions or insertions of a
DNA
sequence. The method was first described by Newton et al. (
1
) for the analysis of single nucleotide differences in DNA from patients with α − 1 antitrypsin deficiency and has since been applied for the carrier detection and prenatal diagnosis of many other genetics disorders including cystic fibrosis (
2
), β thalassaemia (
3
), and sickle cell disease (
4
).
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