The application and mechanism of inflammatory microenvironment regulation stem cells are reviewed.

On June 12, the international academic journal Nature Reviews Nephrology published online a guest review of the Special Review of The Chinese Academy of Sciences, Shanghai Institute of Nutrition and Health Research, by Shi Yuyu (guest), Wang Ying, etc.
article systematically summarizes the molecular mechanisms of interstitial stem cells (mesenchymal stem cells, MSCs) regulating the properties and functions of a variety of immune cells by means of immunomodulation molecules, cell metabolites, cell contact, etc.
In view of the clinical application of MSCs and the regulatory mechanism of the inflammatory microenvironment of MSCs, the possibility of personalized and standardized use of MSCs is proposed, which provides new ideas for stem cell basic and clinical research.
concept was evaluated by international peers as "deusex machina".
MSCs were first found in bone marrow, as part of stem cell nests, has the ability to regulate hematopoietic stem cells self-renewal, proliferation and differentiation, and has the potential to differentiate into fat cells and bone-forming, cartilage cells.
subsequent studies showed that MSCs were present in various organs such as umbilical cord, fat, lung, kidneys, and so on, as matrix cells to maintain environmental stability in the organs.
MSCs can interact extensively and actively with tissue cells, stem cells, immune cells and extracellular matrixes in the microenvironment to regulate the progression and repair of disease under physiological and pathological conditions.
MSCs transplantation has shown good therapeutic results in many inflammatory and damaging diseases, such as transplant anti-host reaction, multiple sclerosis, myocardial ischemia and other diseases.
, more than 700 MSCs-related clinical trials have been registered on the National Institutes of Health's ClinicalTrials.gov database.
the above-mentioned research results have been supported by the national key research and development program, the Chinese Academy of Sciences stem cell pilot special project, the National Natural Science Foundation of China, etc., as well as the Shanghai Institute of Nutrition and Health public technology platform.
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