The application of cholesterol in lipids.

cholesterol can regulate the flow of phospholipid bimoleral membrane, so that membrane permeability is reduced, reduce drug leakage. At the same time, the lipid membrane can maintain a certain flexibility, enhance the ability of lipid vesicles to fight changes in external conditions. And the oxidation of phospholipids has a certain protective effect.preparation of common drug lipids, cholesterol is a necessary add-on, the dosing is generally CHO:PC .3 to 1 (molar ratio). Depending on the PC and the drug, the optimal amount of cholesterol is present. Within a certain range, the particle size, oxidation stability, physical stability and cholesterol addition are positively correlative, and when out of range, the membrane load is exceeded, causing some lipids to rupture. In addition, the addition of cholesterol will have a certain impact on the membrane phase change temperature, the critical value within the phase change temperature reduction, the critical value above, so that the phase change temperature increase.have special dynamic characteristics, in order to reduce the stability of phase change temperature, the rapid release of drugs, can not add cholesterol.
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