The application of cryptoscope technology has become the title of ASC18, the world's largest super-computing competition.

The 2017 Nobel Prize in Chemistry was awarded to three scientists "in the development of cryoscopic electroscopy technology for the determination of high-resolution structures of biomolecules in solutions".
now, the scientific application of the newly awarded Nobel Prize-winning "Frozen Mirror" is the subject of ASC18, the world's largest super-computing competition, and more than 300 teams of college students from around the world will complete the application challenge of the world's top scientific achievement, relion's 3D reconstruction software, in the coming months.
cryoscope is an important method of structural biology research, in order to obtain the structure of biomoleculars such as nucleic acids and proteins, and then explain their functional mechanism.
In the past two years, cryptoscope technology has made the biggest technological leap since the 1970s, with the advantage of cryoscopy technology being better preserved in the structural integrity of biomolecules and high-definition 3D images than X-ray crystal diffraction and nuclear magnetic resonance technology.
using this technology, scientists can study the structure of various biological macromolecules in greater depth, to explore the laws of life activity, and thus understand life.
cryoscopic mirror technology mainly contains three major links, first of all, the sample needs to be quickly frozen, so that the protein and the aqueous solution environment quickly changed from the solution state to the glass state, the glass state can make the protein structure maintain its natural structure state.
then uses cryo-imaging to preserve high-resolution structural information about the sample and obtain a two-dimensional projection image.
finally, the two-dimensional image is calculated by using 3D reconstruction.
for cryptoscope technology, the technical difficulty is far from simple refrigeration, cryo-imaging and image processing algorithms have always been bottlenecks.
Cryoscope technology starts with the freezing-glassization of biomolecular solutions and requires the collection of thousands of high-quality frozen electromirror microscopy in high-throughput, followed by image processing including microphoto correction and evaluation, contrast transfer function (CTF) estimation, particle selection and sequencing, 2D and 3D classification, directional refinement and reconstruction, and post-treatment, which require advanced computational resources with effective algorithms.
In the nearly 30 years since the birth of cryoscopic mirror technology, fast and efficient image processing algorithms, including 3D refactoring, have been the biggest computational challenges in this field.
asC18, which provides a frozen electroscopic data set for human lipoprotein ferrite, asks the team to perform 2D classification, 3D classification, and 3D model reconstruction tasks using the latest overcomputing technology using the most versatile software in the field of cryoscopes. the challenge of
is that the players need to minimize the calculation time while ensuring the final 3.3 Ai resolution.
the documents that the team will need to submit include a document on the presentation and evaluation and optimization methods of overcomputing system environments such as hardware platforms, operating systems, parallel libraries, mathematical libraries, and Relion's output files 2D classified images, 3D classified images, and 3D refactored images.
ASC Student Supercomputer Challenge, the world's largest university supercomputing competition launched by China, gained ground in 2012 and has grown in influence over the past seven years.
so far, the ASC competition has attracted more than 5,500 young talent from around the world, with a total of more than 1,100 teams.
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