The article on products goes directly to the six series of Dongchen MCC co-processed materials

Figure 1.

TMF series

TMF series are co-processing excipients specially designed for orally disintegrating tablets.

TMF955: Microcrystalline cellulose mannitol cross-polymerized wood calcium co-processed product

TMF965: Co-processing of mannitol microcrystalline cross-polymerized calcium

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Figure 2.

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The remarkable characteristics of TMF955 can be seen from the electron micrograph of Fig.

• The particle shape is relatively round, and the product has good fluidity

• High internal porosity of particles and high drug carrying capacity

• Its compression moldability and disintegration performance are very good, see Figure 4

• Shows corrosive disintegration, see video 1

• Especially suitable for orally disintegrating tablets, such as ticagrelor orally disintegrating tablets, etc.

  
  

Figure 4.

TOMITOL™ TMT series

TOMITOL™ TMT series, the Chinese name microcrystalline cellulose mannitol co-processed product , is composed of microcrystalline cellulose and mannitol

Figure 5.
Microcrystalline cellulose co-processed with mannitol

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Electron micrograph

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Functional application

Figure 7.
Compressibility of TMT934

It can be seen from Figure 6 that the order of compressibility is: TMT934>physical mixture>TF525>PH102

Figure 8.
Low sensitivity of TMT934 to lubricants

The salient features of TOMITOL™ TMT series are:

• Possess good compressibility (see Figure 7) and erodibility disintegration
  

• Can significantly reduce the impact of lubricants on pharmaceutical preparations (see Figure 8)

TOMOLLOSE ^® TM series, the Chinese name microcrystalline cellulose sodium carboxymethyl cellulose co-processed product, is composed of microcrystalline cellulose and sodium carboxymethyl cellulose
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Indicator parameters

Figure 9.
Co-processed microcrystalline cellulose carboxymethyl cellulose sodium

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Electron micrograph

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Functional application

The salient features of TOMOLLOSE ^® TM series are:

• With excellent suspension function
  

• Has a good lubricating taste

• Widely used in food thickening, drug suspension, dry suspension

• Application formulations: Clavulanate potassium penicillin dry suspension, Chinese patent medicine dry suspension, etc.
  

TOMCELAC ^® TMC series, the Chinese name microcrystalline cellulose-lactose co-processed product, is obtained by spray-drying the mixture of microcrystalline cellulose and lactose through a special process
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Indicator parameters

Figure 11.
Microcrystalline cellulose lactose co-processed product

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Electron micrograph

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Functional application The salient features of TOMCELAC ^® TMC series are:

• Combines the brittle deformation of lactose monohydrate and the plastic deformation of microcrystalline cellulose

• Has excellent fluidity and compressibility, used for direct compression

• It can increase the hardness of the tablet and can effectively improve the friability index of the tablet

• Suitable for high-dose API formulations

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Indicator parameters

Figure 13.
Co-processed microcrystalline cellulose colloidal silica

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Electron micrograph

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Functional application The salient features of TOMOSIL ^® TMS seriesare:

• Since colloidal silica is a nano-level spherical particle, the fluidity of the co-processed product is improved in detail compared with that of microcrystalline cellulose.
  It is one of the preferred solutions to solve the fluidity problem of solid preparations.
  

• Has good compressibility and dispersion

• Suitable for direct pressure process

Figure 15.
Co-processing of microcrystalline cellulose anhydrous calcium hydrogen phosphate

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Electron micrograph

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Functional application

Figure 17.
Compression moldability of TOP435

It can be seen from Figure 17 that in terms of compressibility: TOP435>physical mixture>TF525>PH102

Figure 18.
Repeated compaction of TOP435

Figure 18 is a tablet test after TOP435 is pressed into plain tablets, broken and then compressed.
The results show that TOP435 has repeated compaction performance, and its repeated compaction performance decreases with the increase of the initial compression pressure
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It can be seen that the salient features of TOMPHOS ^® TOP series are:

• Can be used to solve water-sensitive API formulations

• It is a solution to the problem of repeated compaction of tablets, see Figure 18
  

• Improve tablet hardness and help solve the problems of waist crack, capping and poor friability during tablet compression

• For dry granulation