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    Home > Biochemistry News > Biotechnology News > The bifunctional fusion protein targeting PD-L1/TGF-β was approved by the FDA

    The bifunctional fusion protein targeting PD-L1/TGF-β was approved by the FDA

    • Last Update: 2021-06-16
    • Source: Internet
    • Author: User
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    Article source: Pharmaceutical Guanlan

    On June 2nd, Boji Biomedical Technology (Hangzhou) Co.
    , Ltd.
    (hereinafter referred to as Boji Bio) recently announced that the US FDA approved its self-developed PD-L1/TGF-β bifunctional fusion protein (code name: BJ- 005) New Drug Clinical Trial Application (IND), which can carry out clinical trials in the United States

    .
    This is the second independent research and development product approved by the FDA after the tumor-targeting IL-15 fusion protein (BJ-001) was approved for clinical use in the United States in 2019

    .

    BJ-005 is a recombinant dual-function fusion of a humanized anti-programmed death ligand 1 (PD-L1) IgG1 monoclonal antibody and a part of the extracellular domain of human transforming growth factor β (TGF-β) receptor II The fusion protein can simultaneously target PD-L1 and TGF-β, inhibit tumor growth by targeting immune checkpoints and regulating tumor cell growth cytokine pathways, and is used to treat cancer patients
    .

    Note: The original text has been deleted

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