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A new study from the Icahn School of Medicine at Mount Sinai in the United States offers an important idea of how the body regulates heat production, a process known as the heating effect, which is now a hot topic of research that scientists hope will be used to treat diabetes and obesity.
the past, macrophages(a type of white blood cell) have been thought to play a major role in heating.
but the new study shows that the main driver of heat is the sensory nervous system, which is mainly controlled by the brain.
results were published online online in Nature Medicine.
study was led by Dr. Christopher Buettner, a professor of medicine at Icahn School of Medicine who studies endocrinology, diabetes and bone disease.
the study focused on Catecholamines, a neurotic substance that contains catechols and amines.
and amine base are combined through an enzymatic step of L-tyrosine in the position of the acpathic nerve, adrenal myelin, and chromium cells.
, papyrophenolamine refers to gothyne (NA), epinephrine (Adr) and dopamine (DA).
all three types of cerium phenolamines were converted from tyrosine to presumes.
its role is to activate brown adipose tissue.
brown adipose tissue functions like a "heat-producing device", which produces heat mainly through the non-coupled phosphate decomposition of intracellular fatty acids, producing heat when the body is eating or in the event of cold stimulation.
can also convert white adipose tissue into brown fat-like tissue.
also tested whether macrophages were also a source of theophosphonamine.
Buettner said:
There is a metabolic process that many drugs target to allow the body to burn energy, therefore reducing obesity and improving diabetes symptoms."
macrophages are not so important in this process because they don't produce acetaminophen, but the brain produces acetaminophen through the sensory nervous system.
, it is important to study the role of the brain and the sensory nervous system in understanding metabolic processes.
" heat generation is very important for the survival of the thermostats, including humans, because this prevents deaths from hypothermia.
Buettner said: "Evolutionary stress shapes the biological characteristics of humans and other thermostats, which may partly explain why humans are prone to diabetes in the environment in which we live.
, Buettner says that while we've done a lot to target the immune system for treating diabetes and insulin resistance, there are no effective anti-inflammatory drugs for people with metabolic diseases.
: "Our study suggests that perhaps the key to treating diabetes and obesity is to restore the brain's control over the sensory nervous system and metabolism, as well as the plant nervous system.
"