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    Home > Food News > Food Articles > The brain is aging or this gene is making a fuss

    The brain is aging or this gene is making a fuss

    • Last Update: 2021-03-03
    • Source: Internet
    • Author: User
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    with the advent of an aging society, brain aging has become a topic of increasing concern. Researchers at
    Kunming Animal Institute in China used data from 547 transcriptional groups from 44 brain regions of four young macaques and three elderly macaques to study the potential molecular genetic mechanisms of brain aging in non-human primates and to find new marker genes that can lead to brain aging. The findings are published in the latest issue of the international journal Genomic Biology.
    According to Li Mingli, a member of the Primate Evolutionary Genetics and Development Group at Kunming Animal Research Institute, brain aging is a complex process that relies on precise regulation of multiple brain regions, where as previous studies have often focused on a small number of brain regions, lacking a transcriptional map covering multiple brain regions to analyze the molecular mechanisms behind brain aging.
    based on these large-scale transcription group data analysis, the researchers found that as we age, there is a significant decrease in the expression connectivity between the inner cortectal brain region and between the left and right hemispheres of the cortectal brain. In each brain region, gene expression and selective shearing regulate brain aging through different mechanisms, while the molecular mechanisms of aging between different brain regions are much the same.
    Through a network analysis of transcriptional group data gene co-expression networks in older macaques, the researchers found nine modules that showed increased connectivity in older monkeys, and analyzed a network-critical drive gene, PPLS, which is expressed in older monkeys and may play an important role in brain aging. By overex expressing PPLS in mice, it was found that emerging emerging patterns in mice, such as decreased cognitive ability, decreased motor ability and anorexia, were found. Further biological experiments have also shown that PGLS over-expression leads to synapse loss and apoptosis. As a result, the researchers concluded that it is likely to be a new marker gene for brain aging.
    is understood that this is relying on the "model animal esotopic and genetic research of the country's major scientific and technological infrastructure (primates)" to carry out a research work. This facility will carry out systematic research on primate esmnos and genetic types, and quickly and accurately analyze the esogeotic and inline genetic relationships in the changing phenomena of life, which is of great significance to the research in the field of life science and medical health.
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