The brain slowly becomes silly behind the "black hand" or trans fatty acids.

Original title: The brain slowly become silly behind the "black hand" or trans fatty acids
Recently, the world's first new alzheimer's drug approved for sale in 17 years news strong brush screen, public concern about Alzheimer's disease has increased. Alzheimer's disease is one of the most common types of dementia in old age, and many people are affected by clinical manifestations such as cognitive decline and gradual memory loss. However, you may not know that too much fat in your life can also increase your risk of Alzheimer's and other dementias.
recently,
Japan
researchers published a new study in
American
Institute of Neurology, the journal Neurology, found that eating industrial
foods
rich in
trans fatty acids
increases the risk of dementia such as Alzheimer's disease.
years of poor eating habits, the risk of old dementia increased
fatty acids are the simplest kind of fat, according to molecular structure, can be divided into saturated fatty acids, unsaturated fatty acids. Among them, unsaturated fatty acids, if they contain trans-non-conjugated double-bond structure, are called trans fatty acids.
is a "big family" and, in addition to the most well-known Alzheimer's disease, includes vascular dementia, all-cause dementia and mixed dementia. Starting in 2002, Japanese researchers conducted a 10-year follow-up study of 1,628 Japanese community residents aged 60 and older without dementia, measuring levels of trans fatty acids in participants' serum and using models to assess the risk of all-cause dementia, Alzheimer's disease and vascular dementia in the population.
researchers found that in all three types of dementia, levels of trans fatty acids in the human serum were associated with all-cause dementia and Alzheimer's disease, but not significantly associated with the risk of vascular dementia.
follow-up, 377 participants developed certain types of dementia, including 247 people with Alzheimer's disease and 102 people with vascular dementia. When the researchers adjusted the traditional risk factors for dementia, the body's higher serum trans fatty acid levels were significantly associated with an increased risk of all-cause dementia and Alzheimer's disease in the population, and these associations remained significant when dietary factors, such as total calorie intake and saturation and unsaturated fatty acid intake, were adjusted.
concluded that higher levels of trans fatty acids in the serum may be a risk factor for all-cause dementia and Alzheimer's disease.
fact, the link between trans fatty acids and dementia has long been a concern for researchers. As early as the 1990s, researchers found that people with poor eating habits in ad age had an increased risk of developing Alzheimer's disease in old age, science and technology daily reporters learned. A long-term follow-up study of 2,560 people over the age of 65 living in suburban Chicago found that cognitive decline was faster in older people who ate large amounts of trans fatty acids.
, what are the highlights of this new study?
" risk factors for dementia are many. In the case of Alzheimer's disease, the known risk factors include genetic and environmental factors. Environmental factors include smoking, obesity, diabetes, lack of physical activity, depression in old age and so on. These factors may be interrelated and work. When studying the effects of a single factor on a condition, other risk factors for the condition become "mixed" factors that interfere with the results, said Li Peng, a health science expert at the Beijing Municipal Health And Wellness Commission and deputy director of the Department of Geriatrics at Beijing Stable Hospital at Capital Medical University. The study removed the "mixed" factors of traditional dementia risk and further confirmed the association between trans fatty acid intake and the occurrence of dementia in a similar way to controlling variables. "This is the innovation point of the study." Li Peng said.enter the blood to participate in metabolism, is a variety of diseases
" trans fatty acids why the brain slowly become silly?
" mechanism is not yet fully understanding, but the academic community for trans fatty acids to Alzheimer's mechanism has put forward a variety of hypothrea. Such as trans fatty acids can increase the deposition of A-beta protein in the brain, causing oxidation damage of nerve cells in the brain. Li Peng said.
is the main neuropathological feature of Alzheimer's disease, while A-beta protein is the main component of geriatric plaque. Studies have shown that trans fatty acids increase A-beta protein levels, increase total cholesterol levels, and accelerate arteriosclerosis in the brain. Other studies have shown that trans fatty acids can inhibit cell proliferation and cause oxidative damage to nerve cells by reducing the activity of specific enzymes. The oxidative damage of cells is often related to aging and functional degradation.
addition to dementia, trans fatty acids are also "accomplices" to many diseases. "Previous studies have shown that excessive intake of trans fatty acids may increase the risk of cardiovascular disease, diabetes, obesity and other diseases," Dr. Meng Fanqiang, deputy director of gastroenterology at China-Japan Friendship Hospital, told Science and Technology Daily. Trans
fatty acids increase low-density cholesterol levels and lower high-density cholesterol levels, according to the World Health Organization's official website. High-density cholesterol cleans up cholesterol in the arteries and transports it to the liver and secretes it into bile, while low-density cholesterol is recognized as one of the biomarkers of cardiovascular disease risk. Eating foods rich in trans fatty acids increased the risk of heart disease by 21% and mortality by 28%. In addition, there is evidence that trans fatty acids can exacerbate inflammation and endothysty dysfunction.
" trans fatty acids enter the bloodstream and are involved in human metabolism. Therefore, blood, metabolic-related diseases should be alert to trans fatty acids may have adverse effects. Meng Fanqiang pointed out that the presence of a large amount of trans fatty acids will increase the viscosity of the human blood, increase the possibility of thrombosis, because trans fatty acids are easy to deposit in the body, resulting in abdominal obesity, and obesity can lead to a variety of diseases.
Li Peng told reporters that pregnant or lactating women too much intake of trans fatty acids, through the placenta or milk passed to the fetus, affecting the growth and development of the fetus and baby. Excessive intake in adolescents can also adversely affect the development of the central nervous system.
have no health benefits, mainly from processed food
."Trans fatty acids do not have any known health benefits." According to the official website of the World Health Organization.
since trans fatty acids "crimes" and harm, how can people avoid excessive intake in their daily lives?
first thing to figure out is the source of trans fatty acids. "Some natural foods also contain trans fatty acids, but they come mainly from processed foods." Meng Fanqiang said the naturally occurring trans fatty acids come from ruminants such as cattle and sheep. After the ruminants ingest the feed, a bio-chemical reaction occurs in the stomach to produce trans fatty acids, which are absorbed and then entered into the animal. Therefore, beef, mutton, milk, dairy products will contain a small amount of trans fatty acids.
the research suggests that trans fatty acids in processed foods are produced from hydrogenation of oils and fats, which turns liquids into solids to form a "partially hydrogenated" oil production process. Hydrogenated vegetable oil is the main source of trans fatty acids. Compared with ordinary oils and fats, hydrogenated greases are more stable, less prone to quality, and maintain a solid shape at room temperature, making processed foods more "type" and easier to transport and store. In addition, hydrogenated oil can also increase the taste and taste of food, firmly grasp the consumer's stomach. All foods containing "hydrogenated oil" or fried with "hydrogenated oil" will contain trans fatty acids, such as margarine, margarine and related products, baked with "hydrogenated oil", fried food, etc.
statistics, about 540,000 deaths worldwide each year are related to the intake of industrially ediced trans fatty acids. In 2010, the average global trans fat intake accounted for 1.4 per cent of total energy intake, with countries ranged from 0.2 to 6.5 per cent and accounted for 0.13 to 4.3 grams of the 2,000-calorie-a-day diet. Based on the small amount of information available, North America, Latin America and North Africa/Middle East have the highest intakes, and young people generally have higher intakes.
based on a total daily intake of 2,000 calories, the World Health Organization recommends limiting daily trans fatty acid intake to 2.2 grams. According to China's food safety-related requirements, food packaging should be labeled trans fatty acid content, the public can be used for reference when buying.
"It's important that people consume as few trans fatty acids as possible in their daily lives and maintain healthy eating styles and habits," he said. Meng Fanqiang expressed the hope that the harm caused by trans fatty acids in the future will be well prevented and controlled.
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