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On July 23 , the international academic journal PLOS Pathogens published online a research paper from the Shanghai Institute of Pasteur Institute of Chinese Academy of Sciences Zhong Jin's research paper: Glycometabolism regulates hepatitis C virus release
Hepatitis C virus ( hepatitisCvirus , HCV ) is a positive-stranded RNA virus that can cause chronic hepatitis, cirrhosis and liver cancer
However, due to the existence of metabolic reprogramming, tumor cells and normal somatic cells have significant differences in a series of metabolic pathways such as sugar metabolism
Many previous studies have found that if the sugar source in the culture medium is changed from glucose to galactose, it can force tumor cells cultured in vitro to weaken glycolysis and switch to oxidative phosphorylation as the main energy supply method
In this work, the researchers found that culturing Huh7 cells in a medium that uses galactose as a sugar source can significantly inhibit the release of HCV virus particles, but does not affect HCV cell entry, replication, assembly and maturation
The study also found that the direct transmission of HCV between cells is not affected by host cell sugar metabolism.
Legend: The model diagram of glucose metabolism regulating HCV release
This research work was mainly completed by Dr.
Paper link: https :// journals .