The chinese Academy of Sciences Kunming animals found that the progress of AIDS in the elderly key factors

recently, the Kunming Institute of Zoology of the Chinese Academy of Sciences animal models and human diseases, the key laboratory Zheng Yongtang discipline group found that immune aging is a key factor in the progress of AIDS in old age, the results published online on
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At present, the treatment effect of HIV-infected people in middle-aged and old age is not ideal, the bottleneck lies in the difficulty of longitudinal study of the pathogenesis of AIDS in the whole process of HIV infection, the key to solve the problem lies in suitable animal models, but so far there is no research report on animal models of elderly AIDS.
Zheng Yongtang group used SIVmac239 virus infection of elderly Chinese macaques for the first time to establish an elderly AIDS animal model, found that immune aging in the development of AIDS in old age play a key role. After infection, the blood plasma virus load of elderly monkeys increased rapidly, the CD4/CD8 ratio was severely inverted, and the CD4-T cells decreased rapidly, indicating a higher risk of disease progressing faster and developing into AIDS. Some characteristic indicators of immune aging, such as low levels of CD4 plus initial T-cell ratio and high levels of steady-state proliferation after infection, indicate further disease progression. The host natural immune response of elderly monkeys is faster and stronger, which is related to its rapidly increasing steady-state proliferation level and severe CD4-plus initial T-cell depletion, and network analysis has found that immune aging is the central factor. Although this compensation effect can alleviate the loss of CD4 plus initial T cells in elderly monkeys to some extent, it actually aggravates the host's immune activity and inflammation, thus accelerating the progression of the disease. Results Show that SIV infection of elderly Chinese rhesus monkeys is a good animal model to study the pathogenesis of AIDS in old age, and the treatment of AIDS in old age should pay attention to reversing immune aging and controlling abnormal immune response. (Source: Science Network Guo Shuang)