The Chinese Union of Scientists Research reveals the immunological characteristics of neo-coronary pneumonia

Understanding and understanding the pathogenesis of neo-crown pneumonia is of great significance to its diagnosis and treatment and prevention and control.
the research alliance, which was spontaneously organized by Chinese scientists, revealed the existence of new infection mechanisms and the characteristics of the body's immune response at different stages of disease onset by establishing large queue data of single-cell transcription group of new coronary pneumonia.
published online in Cell, an internationally renowned academic journal.
the wide application of single-cell transcription group sequencing technology in various fields of life science has given birth to many important biological discoveries.
, however, the application of this technique in the study of new coronary pneumonia has problems such as high cost, small sample size, statistical effectiveness and insufficient universality of conclusions.
In order to solve the above-mentioned problems, more than 40 hospitals, universities and research institutions in more than 10 provinces and cities in China spontaneously formed the "New Coronary Pneumonia Single Cell Research China Alliance" in May 2020 to jointly establish a large queue of large data in the single-cell transcription group of New Coronary Pneumonia.
alliance obtained single-cell transcription group sequencing data from 284 samples of nearly 1.5 million cells from 196 new crown patients, and quickly completed the integration and analysis of the data. the
study found that, in addition to the traditionally thought respiratory endocysts, new coronavirus nucleic acid sequences have been detected in a variety of immune cells, suggesting that the virus has been active in these immune cells transcription and replication, that is, immune cells can not be ruled out as the new coronavirus host cells.
may be an important feature of the new coronavirus different from the SARS virus, or it may be the cause of the new coronavirus has a strong infectious power.
this finding is consistent with a strong interferon response in neocytovirus nucleic acid-positive cells and has been confirmed by tissue slicing and staining of the new coronavirus S protein.
note that the new coronavirus subject ACE2 is barely expressed in immune cells, suggesting that the new coronavirus may have potential new subjects to infect host cells.
Cheng Tao, director of the Hematology Hospital (Hematology Institute) of the Chinese Academy of Medical Sciences, which participated in the study, said that the results of the study provide new understanding and clues to reveal the pathogenesis and immune characteristics of neocytosis, and are of great significance for finding intervention targets and treatment measures for neocytosis from the perspective of immune cells.
The member units of the "China Alliance for single-celled research of new crown pneumonia" include Peking University, Naval Medical University, Guangzhou Biological Island Laboratory, Shenzhen Bay Laboratory, Beijing You'an Hospital affiliated with Capital Medical University, China University of Science and Technology, Shenzhen Third People's Hospital, Harbin University of Technology, Institute of Biophysics of the Chinese Academy of Sciences, Zhongshan University, Chinese Academy of Medical Sciences Hematology Hospital (Hematology Research Institute), Army Military Medical University, etc.
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