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    Home > Food News > Food Articles > The Chinese University of Science and Ology found neurons in the brain that "fight or escape"

    The Chinese University of Science and Ology found neurons in the brain that "fight or escape"

    • Last Update: 2021-03-04
    • Source: Internet
    • Author: User
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    Xinhua Hefei, February 26 (Reporter Wu Lan) reporter 26 from the Chinese University of Science and Technology was informed that after eight years of research, researchers at the university found that the brain responsible for stress response behavior neurons, decrypt the famous scientific problems "fight or escape" choice, in order to improve or treat negative stress-related disorders and diseases, put forward new ideas and ways.
    study was published online February 25 in the journal Neuron.
    in a natural and society full of stress, every individual facing stress will make a choice: active response or passive avoidance. What is the biological basis of the brain responsible for this ability to make this choice? This is a well-known scientific question, which Jane calls the "fight or escape" option.
    researchers often judge the coping strategies they choose when faced with stress based on the behaviors used by animals. Using techniques such as gene-operated mice combining behavior, drug genetics and in vitro microimaging, zhou Jiangning research team at China University of Science and Technology found that in various behavioral challenge scenarios, the adrenal corticosteroid-promoting hormone (CRF) neurons in the inner frontal loess are the neurobiological basis for deciding to "fight or escape".
    , the study first identified CRF neurons in the inner frontal frontal leaf as an inhibitory intermediate neuron and formed a neural loop with vertebral neurons. Then, using live microimaging, it was observed that CRF neuron activity increased when mice took active coping behavior under negative pressure. Under negative stress conditions such as overhanging tail, forced swimming and social competitive frustration, the use of chemical genetic methods to apoptosis or inhibit the internal frontal preletetain CRF neurons can increase the passive coping behavior of mice, while the activation of CRF neurons promotes active coping behavior.
    Individuals exposed to negative stress for a long time can still maintain normal physiological and psychological stability, known as "resistance" to negative stress, while in long-term negative pressure, can not maintain normal physiological and psychological stability, is called negative stress "susceptible." Epidemiological and clinical evidence suggests that individuals who are accustomed to reactive behavior have an increased risk of stress-related mental, physical, or mental illness, known as susceptibility. The study further studied the role and mechanism of pre-frontal CRF neurons in producing "resistance" behavior in mice. In the case of long-term social competition failure, 80 percent are shown as "susceptible type", using chemical genetic methods, the selective activation of the inner frontal preleteum CRF neurons can significantly increase the active coping behavior of mice, the proportion of "resistance" mice greatly increased. It is worth mentioning that the effect has a long duration.
    the study revealed that the inner pre-frontal CRF neurons are neurons in the brain responsible for regulating stress response behavior. Promoting the activity of CRF neurons in the inner frontal frontal leaf can enhance active coping behavior and increase resistance to negative pressure on the environment. This finding promotes an understanding of the important scientific issue of "stress response behavioral choices" and suggests new ideas and ways to improve or treat negative stress-related disorders and diseases.
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