The conclusion of the study of deer antler regeneration mechanism.

If a human had a 10 cm wound, it would not have healed quickly and without scarring, but deer antlers could do just that.
previously, the domestic research on deer antlers is still in the composition, medicinal category, in fact, deer antlers as the mammal's only completely regenerative subsidiary organs, its extraordinary significance but long-term lack of attention.
more than 30 years, The Chinese Academy of Agricultural Sciences specialty institute researcher, special economic animal molecular biology ministry co-construction of the national key laboratory executive deputy director Li Chunyi has been deep in the field of deer antler regeneration, this persistence and persistence finally kept the cloud to see the moon, he successfully revealed the regeneration mechanism of deer antlers, for the field of regenerative medicine to provide an excellent research model.
won the first prize of the 2017 Jilin Provincial Natural Science Award.
the goal of life: the benefit of human organ loss or failure of function is the two major problems facing human health, the most important response is to transplant new organs, but to fundamentally solve the problem, the study of defective organ regeneration is the key.
mammalian organ regeneration is the commanding point of regenerative biology and regenerative medicine.
"can fully regenerate limbs and organs like a dragonfly" is the long-standing aspiration of human beings, although the phenomenon of regenerative slugs is desirable, but the process of de-differentiation and redifferentiation is unique to low vertebrates, mastering the knack of regenerative slugs does not mean that human beings can "replicate" this ability.
, and Li Chunyi captures the importance of deer antler regeneration.
" Deer antlers are the only mammalian organs that can be fully regenerated after loss, providing us with an opportunity to understand how nature solves the mystery of the complete regeneration of mammalian organs."
," Li Chunyi told China Science Daily.
if it can reveal the mechanism of full regeneration of deer antlers, it may induce amputation, broken leg, broken finger re-growth, can benefit mankind is Li Chunyi's life-long goal.
as early as 1982, When Li Chunyi was studying for a master's degree, he began his research in the field of deer antler regenerative biology.
the battle for deer antler regeneration has been going on for more than 30 years.
from 1985 to 1990, Li Chunyi realized the regeneration of the deer twice a year (naturally, the deer is only born once) and the female deer raw antlers (naturally only the deer is born), these two achievements not only theoretically achieved a major breakthrough, but also produced huge economic benefits, net income of more than 100 million yuan.
for this purpose, Li Chunyi won the "China Youth Science and Technology Award" from the Chinese Association of Science and Technology in 1990.
, however, Li Chunyi has not stopped moving forward.
began a series of exploratory research estoccosis on deer antlers in early 1991 as part of the Invermay Research Centre of the Royal Agricultural Sciences of New Zealand, then considered the World Deer Antler Research Centre.
these have laid a good foundation for the dream of the benefit of mankind.
get the "key" of mammal regeneration, li Chunyi realized that there was still a long way to go before the human limb regeneration could be achieved from the deer antler regeneration route.
1993, Li Chunyi studied for a PhD at the University of Otago University of Medicine in New Zealand, where he chose to track deer antler seisgenerator stem cells using marker genes.
while reading the bo, he discovered and pinpointed the functional cell cluster saedumofs, the horn edor (the bone pile of the deer's head, the tissue base of the deer's antler regeneration), the bone membrane cell group.
qualitative studies of diagonal bony membrane cells have found that they are a special type of stem cell between adult stem cells and embryonic stem cells and are defined as deer antler regenerative stem cells.
Li Chunyi not only proposed for the first time, but also experimented with proof that the complete regeneration of deer antlers is based on the existence of such stem cells.
"different organs and tissues have different stem cells, and deer antlers have a very special stem cell."
" Li Chunyi introduced, he took the stem cells from the long furry place, found that the original place can not grow, put it in other parts of the deer body, other parts began to grow antlers.
"planted" on the head of a mouse will grow long.
that is, the isolated deer antler regenerative stem cells can induce ectopic hair.
discovery of this particular stem cell, like getting the "key" to regeneration.
also discovered and located the microenvironment of deer antler regenerative stem cells, the endothelial cortex of horned skin, identified several key cell types that make up the microenvironment of deer antler stem cells - true fur nipple cells and epidermal cells, and then established an exosome culture system of deer antler regenerative stem cells and their microenvironment cells, which laid the foundation for the separation and identification of the molecules associated with deer antler regeneration.
the publication of the research, there has been a significant international response in the field of renewable biology, for which Li Chunyi has been awarded the Outstanding Scientist Award by the World Research Promotion Council.
2013, Li Chunyi decided to return home, "if you want to further reveal the mechanism of deer antler regeneration, the domestic scientific research environment can not be better."
here, you can develop a team of young people with team cohesion."
in the ministry to build a national key laboratory, Li Chunyi built a nearly 30-person laboratory team, this team is mainly composed of graduate students, doctors, post-doctoral, for deer antler research continue to inject fresh blood.
after years of collaborative research, the molecular mechanism of full regeneration of deer antlers has been thoroughly understood.
" and then applied this mechanism to experiments on mouse amputations, and found that a new growth center was induced at the mouse's amputation, resulting in a small partial regeneration.
even partial regeneration, this progress is remarkable for mammals.
," Li Chunyi said.
amputation is very complex, involving bones, bone marrow, muscles, blood vessels, nerves, fat, etc., the team found that one of the main reasons for the amputation can not regenerate, is due to its long bone membrane cells (deer antler regenerative stem cells) division and reproduction potential is not.
and the potential for split reproduction of deer antlers is almost limitless, and the whole organization of amputations is so complex that it is attributed to a cell that minimizes the problem, so long as the cell increases the growth and division reproductive potential, other tissues grow.
based on this, Li Chunyi first put forward the "stem cell-dependent" mammal's amputation hypothesis.
hypothesis is different from the current "germ dependence" view of low-level animal limb regeneration.
the "stem cell dependence" hypothesis locates the entire regeneration process into a cell, a broken osteoblast (stem cell).
, he suggested that if modern technology could be used to give long bone membrane cells great potential for division, there is a good chance that mammals (including humans) will have a broken limb regeneration.
, Li Chunyi led the team to treat skin damage in rats and dogs with deer antler stem cells, achieving perfect regenerative healing.
next, they will further optimize the conditions and try to extend the break further.
In addition, "We intend to do two things, the first is to develop some scar-free wound healing products, and the second is to achieve bone repair."
hope that in the future strive for the early realization of the human dream of physical regeneration." li Chunyi,
, said.
.