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    Home > Medical News > Medical Research Articles > The current situation and mode of research on the modernization of Traditional Chinese medicine

    The current situation and mode of research on the modernization of Traditional Chinese medicine

    • Last Update: 2020-07-05
    • Source: Internet
    • Author: User
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    The essence of the modernization of Chinese medicineis the combination of Traditional Chinese medicine and modern science and technology, the combination of modern academic thought, the combination of modern scientific culture, and theand norms of internationally recognizedstandards, so that Chinese medicine is more in line with the needs of modern people, research and development of safe,stability,,controllable Chinese medicineTraditional Chinese medicine and compound play the effect has the characteristics of integral,multi-target and multi-component synergy, the clarification of the basis of Chinese medicine effect substances is the basis of quality control of Chinese medicine, is the key to interpret the mystery of the role of Chinese medicine, but also the core of the modernization of Chinese medicineFirst,,the current situation and problems of the research of Chinese medicine and pharmaceutical effect substances
    the Chinese medicine effect substances refer to the chemical composition system of Chinese medicine and compounding to play a pharmacological role, and is the basis and core of quality control of Chinese medicineBecause of theof the whole function of Chinese medicine,the complexity of the composition and mechanism of Chinese medicine, how to find the drug-effective substance suitable for the complex system of Chinese medicine, how to clarify the basis and the nature of the action of the substance is the main "bottleneck" to restrict the modernization of Chinese medicine1The advantages of the study mode of multi-component theory of Chinese medicine
    poly-component theory refers to the speciality of pharmaceutical
    substances except protein, macromolecule tannin, resin, heavy metal ions, oxalic acid and other small molecules,conforms to the speciality of Chinese medicine with multi-component, multi-target and multi-channelThe research on the basis of Chinese medicine effect substances is the keyof quality control of Chinese medicine and research and development of new medicine,the problem of single high-selective target screening is difficult to solve the problem of Chinese medicine compound active ingredient screening
    ,multi-component analysis method based on the whole view provides a good way of thinking and entry point to solve this problemThe advantage of multi-component theory is that it does not have to clarify theof all pharmaceutical-effective substances,avoid sandandy purification and separation procedures, do not have to find out the of the distribution of various pharmaceutical-effective substances, the proportion of the drug-effective substances, and use the fingerprint map
    of traditional Chinese medicine as a means of quality control, can basically guarantee the quality of drug The fingerprint map of Chinese medicine as a new type of production quality standard of Chinese medicine, can ensure the consistency, efficacy and reliability of drug The fingerprint map of Chinese medicine refers to the map of the common peak of Chinese medicine raw materials
    , drinking tablets, semi-finished products, finished products, etc after proper treatment, using certain analytical means, and obtaining a map of the common peak that can express its characteristics Fingerprint map of Traditional Chinese medicine is a comprehensive, quantifiable chemical (
    not including biology) identification means, can identify the authenticity, evaluation of raw materials
    the of medicinal materials, semi-finished products and finished productquality homogeneity and stability, its basic characteristics are integrity and fuzziness Multidisciplinary cross-expansion of the technical means of Chinese medicine research, fingerprint mapping analysis methods for Chinese medicine active ingredient sifting, the basis of the drug effect seisphon and quality control of Chinese medicine provides a powerful means, shorten the analysis time and workload 2
    The confusion of the research mode of Chinese medicine multi-component theory the study mode of Chinese medicine multi-component theory is one of the main "bottlenecks" of the modernization of Chinese medicine, which is insufficient in the quantification, precision and quality control of Chinese medicine At present, the fingerprint map of Chinese medicine is one of the main means of the research mode of Chinese medicine multi-component theory, with the continuous in-depth study of Chinese medicine, has produced a lot of confusion One of the confusions, the comprehensive extraction method of The Chinese medicine fingerprint map may deviate from the original Chinese medicine compound drug-effective substances, because the need to take a variety of solvents, multi-process ingenual extraction of the original Chinese medicine pharmaceutical effect substances, and each solvent on different pharmaceutical components extraction efficiency is very different, after this many times, different solvent extraction and concentration, the proportion of the drug effect substances may not be exactly equivalent to the proportion of the original compound, and the same compound ingression process may also take different proportions Confused second, the integrity and fuzziness of the comprehensive extraction of the fingerprint map of Chinese medicine, it is not yet possible to know the specific compounds of the pharmaceutical effect substances, or only know a few main components and the proportion between them can not be detected, which completely solves the problem of slow chinese medicine and the design of new dosage forms brings difficulties Confused three, The Chinese medicine fingerprint map as the final quality control index of traditional Chinese medicine also has shortcomings, first, may be different batch number of products due to the difference in Chinese medicine raw materials, preparation process of any small operation changes, color column itself in the experimental process of changes lead to fingerprint map differences; Multi-component theory supports the "complex- complex" thinking of the modernization of Chinese medicine, that is, by various means, from the Chinese medicine to extract all ingredients, remove invalid ingredients, retain the medicinal effect substances, give full play to the overall advantages of Chinese medicine and compound, in the inheritance of traditional Chinese medicine compound ingenuity on the basis of reform However, the essence of the modernization of Chinese medicine is the combination of Traditional Chinese medicine and modern science and technology, the combination of modern academic thought and modern scientific culture, which is not well reflected in the research mode of Chinese medicine multi-component theory Second, the new mode of the modernization of Chinese medicine research - limited active ingredient theory
    limited active ingredient theory refers to the actual absorption of blood components and play a therapeutic role of the pharmaceutical substances are a small number of limited The theory of limited active ingredients supports the "complex- simple-complex" thinking of the modernization of Traditional Chinese medicine, that is, to extract effective monomer ingredients from Traditional Chinese medicine, and then to make it into a suitable formulation in a certain way, to carry out clinical screening, to find out the best monomer preparation scheme This method, the drug composition content is accurate, the production process and quality can be controlled, animal experiments and clinical testing indicators can be measured, from this stage is easy to meet international norms, but it is a "double-edged sword." The advantage of limited active ingredient theory is that it can strictly control the production process indicators and the quality of drugs, can fully control the pollution of harmful substances, such as heavy metal ions, residual pesticides and other harmful substances, easy to carry out dosage form reform, that is, according to the various physical and chemical characteristics of each monomer compound, to find suitable drug carriers and preparation technology; The current difficulty is the screening and extraction of pharmaceutical substances, each medicine has hundreds or even thousands of different compounds, to find out its active substances, and to extract and separate, is not an easy task, even if the drug-effectsubstances, these single ingredients do not necessarily have obvious medicinal effects, the limited kind of compounds must be reasonable, can play the overall role of Chinese medicine compound, and many scholars think that it has traditional the theory of traditional chinese medicine But any science should be an open system, actively absorb modern science and technology, in order to develop with the times The traditional compound itself is based on experience, which still contains considerable non-active ingredients, and the overall synergy emphasized by Chinese medicine is not the synergy of all components in the complex Therefore, it may be useful to introduce the theory of limited active ingredients into the field of chinese medicine research, and with the help of modern science and technology to clarify the drug-effective substances and mechanism of Chinese medicine, and then in-depth study of the four-gas-five-flavored, up-lifting and sub-theory, to complicate, at a higher level to return to the original nature of Chinese medicine, to achieve the modernization of Chinese medicine is worth exploring 2
    1st century is the information age of science and technology, Chinese medicine want to create brilliant, and step into the modern hall of science, we must open their hearts, stretch their arms, warmly embrace the world's multidisciplinary new technologies, new achievements, from which to draw the essence for my use, may break the "bottleneck" of the modernization of Traditional Chinese medicine opened up a new perspective (
    Li Xihai Liang Wenna Liu, /
    of Fujian Central College)
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