The development pattern of the beautiful hidden rod worm is related to the change of unsaturated fatty acids in membrane lipids.

There is a non-aging development pattern in the beautiful hidden rod worm, which is mainly manifested in the persistence of larvae to stop developing and prolong their survival as long as possible, but the specific regulatory mechanism is not clear.
The tax-gloss research group of the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences, starting with lipomic histological analysis and related gene transcription level regulation, analyzed the changes of specific lipid groups on membrane lipids during the aging and death of persistent larvae, and found that polyunsaturated fatty acids were rich in membrane phospholipids entering the umptogenous state of persistent larvae compared to other developmental periods of nematodes.
further studies have found that polyunsaturated fatty acid content in membrane phospholipids of persistent larvae accumulates gradually in the first half of maintaining larvae tolerance.
when persistent larvae begin to die, polyunsaturated fatty acids in membrane lipids suddenly decrease, and free polyunsaturated fatty acids and their downstream oxidizing derivatives increase significantly.
lipid histological analysis shows that polyunsaturated fatty acids are rich in phospholipid membranes and play an indispensable role in the sleep of lysophageal nematodes, whose main function is to inhibit the formation of peanut acid-like substances from downstream products, and to break the balance of membrane lipids will cause the death of persistent larvae or withdrawal from the toes.
the study revealed that changes in unsaturated fatty acids in membrane lipids may be one of the most important factors affecting the longevity of beautiful cryptobacteriats.
results have been published online in redox Biology (DOI:10.1016/j.redox.2017.05.002).
Lam Sin Man, Ph.D., and Wang Zehua and Li Wei, co-authors of the paper, are the co-authors of the paper.
project has been funded by the Chinese Academy of Sciences strategic pilot project, the National Natural Science Foundation of China project, China postdoctoral special fund project.
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