The dry granulation process with high environmental protection and energy saving will gradually replace the wet granulation process

Today's pharmaceutical industry has become more and more dependent on pharmaceutical equipment Only when a set of granulation process is completed, can the next tablet pressing, capsule filling or direct packaging of APIs in the form of granules be carried out Generally speaking, there are two kinds of pelletizing equipment at present: dry pelletizer and wet mixed pelletizer Among them, the wet mixing granulation equipment needs a lot of adhesives, and the waste water generated by cleaning causes pollution to the environment In addition, the wet particles have a wide range of mesh size distribution, uneven distribution and many fine powders, which are generally used for tablet or capsule filling So, let's talk about the obvious advantages of dry granulator? (1) compared with wet granulation, dry granulation has less equipment, lower maintenance cost and less floor space, so its production cost is low (2) compared with wet granulation, dry granulation is simpler with fewer intermediate links, which can control dust flying and reduce powder waste At the same time, there is no exhaust emission and environmental pollution reduction (3) compared with wet granulation, dry granulation has the advantage of low energy consumption, because dry granulation does not need to be humidified and then dried (4) dry granulation does not need to add any adhesive; some drugs (antibiotics, strong heat sensitivity) and extracts of traditional Chinese medicine can not meet the specific weight requirements, and can not add adhesive, which must be completed by dry granulation process (5) after dry granulation, the particle size of the finished product is uniform, the bulk density is increased, the fluidity is improved and the disintegration degree can be controlled, meanwhile, it is convenient for subsequent processing, storage and transportation (6) in the process of dry granulation, the medium pressure wheel is cooled by the forced circulation of the refrigerator, which not only has a good cooling effect but also does not consume water resources Therefore, there is no waste gas or waste water in the granulation process The cleaning process is simple and convenient Apart from the pressure wheel, the granulating parts can be disassembled and cleaned, and the production equipment is less, so the produced sewage is less Energy conservation is mainly to strengthen the management of energy consumption, take measures that are technically feasible, economically reasonable and affordable for the environment and society, reduce the loss and waste in all links from energy production to consumption as much as possible, and make more effective and reasonable use of energy; reducing consumption is to reduce investment and consumption in production Through the comparison of many cases, we can conclude that the cost and energy consumption of dry granulation from equipment input to product output are much lower than that of wet granulation With the continuous improvement of the dry granulation process and the gradual shortage of energy, the dry granulation process will gradually replace the investment of the wet granulation line.