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On August 14th, the international academic journal Cell Discovery published the results of the Chen Jiangye Research Group at the Institute of Biochemistry and Cell Biology of the Chinese Academy of Sciences, "Merge and separation of NuA4 and SWR1 complexes control cell fate plasticity in Candida albicans".
the study revealed the regulatory mechanism of the integration and separation of histone acetyl transferase complex NuA4 and chromaret reshaping complex SWR1 during the conversion of the color canary loitering bacteria, and it is speculated that the fusion of NuA4 and SWR1 complex is of great significance in the evolution of eukaryotes.
candida bacteria is a human opportunistic pathogenic fungus, in a variety of forms parasitic in the human body, including yeast and mycosin, its morphological conversion ability is directly related to its pathogenic ability. The transformation of yeast-mycelium morphology in
is influenced by a variety of external stimuli, and is regulated by a variety of transcription factors and chromatin modified complexes within cells.
histone acetyl metastase complex NuA4 and chromatin remodeling complex SWR1 are evolutionaryly conservative compounds in eukaryotic cells.
previous studies have shown that NuA4 and SWR1 are two independently existing but synergistic compounds in low-level eukaryotic organisms such as wine yeast, while in higher eukaryotic organisms such as humans, NuA4 and SWR1 merge into a large complex called TIP60, which also owns members of both NuA4 complex and SWR1 complex.
in the study, the researchers found that in yeast-like candidobacteria cells, NuA4 and SWR1 compounds can fuse to form a large complex, similar to human TIP60, while in mycosphinized cells, NuA4 and SWR1 are divided into two separate compounds, similar to the composition of wine yeast.
the fusion of NuA4 and SWR1 complexes is achieved through the platform protein Eaf1 anchor of the NuA4 complex, which is scheduled to be identified by Yaf9 on the SWR1 complex, and the core enzyme Esa1 of the NuA4 complex mediates acetylation of Eaf1 K173, thus being identified by Yaf9's YEATS domain, thus bridging two complexes.
in the mycelium development process, mycelium-specific transcription factor Brg1 can recruit the acetylationenzyme Hda1, thereby removing the acetylation of Eaf1 K173, directly leading to the separation of the two complexes.
this study is the first to prove that the dynamic separation of NuA4 and SWR1 complex directly regulates gene expression of the yeast-mycelium morphomorphological transformation of Sancanta, revealing a new mechanism for the integration and separation of NuA4 and SWR1 complex in the regulation of cell destiny plasticity.
under the guidance of researcher Chen Jiangye, the research work was completed by Dr. Wang Xiongjun and graduate student Zhu Wencheng, and received the strong support of Professor Liu Haoping of the University of California, Irvine, and the financial support of the Chinese Academy of Sciences and the National Natural Science Foundation.
.