The epidemic is not going on. Is America panicking? |Lock pangolin and add new card!

Author: today's news from biotech king gives us a little more confidence There are 16 new confirmed cases outside Hubei, and less than 100 cases in three consecutive days Maybe, a lot of people think today's title is "rumors and articles", good! I just want to use the following facts to explain why those rumors and conspiracy theories have no logical and scientific basis What economic globalization brings is the mutual dependence and mutual influence between countries China has been actively responding to economic globalization, has undertaken international industrial transfer, participated in international division of labor, and become a world factory As a result of individual people's greedy for game, the whole country and even the world have fallen into an unprecedented state of stagnation or uncertainty There is growing concern that the supply of drugs may soon face disruption on a global scale Rosemarie Gibson, author of China Rx, recently told the U.S - China Economic and Security Review Committee in Washington, D.C., that it is estimated that 80% of all active pharmaceutical ingredients (drug ingredients) are produced in China and India These include compounds used to treat everything from bacterial infections and cancer to heart disease and diabetes As many pharmaceutical factories in China are still closed, the inventory of many medicines may soon be in a hurry "This is a very serious problem right now," said Michael Osterholm, director of the center for infectious disease research and policy at the University of Minnesota In life-threatening situations, there are 153 drugs that patients need to use immediately Even before the outbreak of the new coronavirus, over dependence on a small number of suppliers led to a shortage of dozens of drugs every day These supply chains are very weak " But marigangela SIM ã o, who's assistant director general for access to medicines and health products, said she and her colleagues have yet to see signs that covid-19 affects the supply of essential drugs SIM ã O's team maintains daily contact with the international pharmaceutical associations, which are tracking the disruption of transportation by their member companies "The information we have so far is that there are no immediate risks associated with APIs," said SIM ã o She added that part of the reason was that many companies hoarded products two to four months before the Spring Festival holiday, when many factories were closed Although there are some pharmaceutical companies in Hubei, more are located in Shanghai and other less affected areas of China However, SIM ã o pointed out that if the virus is not under control, there is still the possibility of drug supply disruption "It will all depend on how the epidemic evolves," she said This sense of uncertainty about what is going to happen is probably the most common concern in China and around the world The influence of scientific research comes back to the current situation of scientific research: universities all over the country are still not open, laboratories cannot be used, research projects are sealed, field work is interrupted, and academic exchanges are severely restricted Not only domestic, but also scientists from other places abroad have noticed the impact Cooperation with China has been suspended, and academic conferences in the next five months have been cancelled or postponed For individual researchers, the loss may be more severe John Speakman, director of the laboratory of animal behavior of the Chinese Academy of Sciences, said: "it basically stopped, and the loss was huge We're really under a lot of pressure " But he expressed understanding and support for all measures taken by the Chinese government to control the epidemic Wei Wensheng, a geneticist at Peking University, said: "we don't know when the epidemic will end and when we can get all the lab members back to continue our project." Pu Muming, a neuroscientist at the center for excellence and innovation in brain science and intelligent technology of the Chinese Academy of Sciences, said: "because students and researchers are not allowed to return to the laboratory, the current experimental research has basically stopped." At the same time, many universities and research institutions have added online courses to ensure that students attend classes on time Professor Pu says he teaches two hours of neurobiology every day Surprisingly, thousands of people learn online every day Daniel Kammen, a renewable energy researcher at the University of California, Berkeley, said this hindered his lab's efforts to help build green transportation projects across China "The outbreak of the coronavirus has delayed our oil field development plans, including the promotion of electric taxis in Chinese cities," he said The crisis has also overloaded some laboratories The novel coronavirus is currently being studied by Zhang Linqi, an HIV researcher at Tsinghua University "My lab quickly reoriented its research," he said Last month, members of his lab gave up celebrating the Spring Festival They urgently synthesized and described the spike on the surface of the coronavirus, a protein that helps it enter human cells Zhang said the findings point the way for several vaccine strategies the team is currently exploring with partners "I work more hours now than ever before," said Sara platto, a professor of animal behavior at Jianghan University Platto and a team in Beijing are conducting genetic analysis to determine the relationship between sars-cov-2, the virus that causes covid-19, and another coronavirus isolated from pangolin She said she participated in 13 online groups to keep the research going But her paper was delayed because she had left her notes in the office before the epidemic and was unable to return to school When it comes to pangolins, a team led by Professor Guan Yi, director of the State Key Laboratory of new infectious diseases at the University of Hong Kong, found new pangolin samples very similar to the deadly sars-cov-2 in Guangxi and Guangdong anti smuggling operations on February 19, Beijing time, in a heavy study published on the preprint website biorxiv (without peer review) Coronavirus! The novel coronavirus is the novel coronavirus as potential intermediate host after the announcement of the discovery of the potential intermediate host of the new coronavirus by South China Agricultural University (Hua Nong: pangolin is the potential intermediate host of the new coronavirus) This study proves that coronavirus is widespread in wild animals, far more than bats or civets It is of great significance to thoroughly solve the mystery of the source of sars-cov-2 virus According to the study, Guan Yi's team collected 43 tissue samples of 18 frozen pangolins (lungs, intestines, blood) seized by Guangxi customs during the anti smuggling operation from August 2017 to January 2018 Through genome sequence, we found that these viruses have similar genome to sars-cov-2 Based on these new genomic sequences to determine whether the original samples were positive, the researchers tested another group of pangolin samples collected between May and July 2018 In 19 samples (9 intestinal tissues and 10 lung tissues) of 12 animals, three lung tissue samples were found to be positive for coronavirus The paper points out that in addition to these animals from Guangxi, after the outbreak of sars-cov-2, Guangzhou Customs Technical Center retested 5 pangolin samples (2 skin samples, 1 tissue location, 1 scale) obtained in the anti smuggling operation in March 2019, and the high-throughput sequencing of scale samples also detected the coronavirus fragments It is worth noting that another study on the prevalence of pangolin in Guangdong Province in 2019 also found a virus overlap group similar to sars-cov-2 in lung samples Through different assembly methods and artificial screening, 86.3% of the total genome of the virus (labeled GD / P1l) was obtained The genomes of these coronaviruses found in pangolin are 85.5% - 92.4% similar to those of sars-cov-2, and represent two subtypes of sars-cov-2 in phylogenetic tree, among which GD / P1l and Gd / p2s are closely related to sars-cov-2 Photo source: so far, pangolin is the only mammal other than bats infected with sars-cov-2-related coronavirus In this study, the team found two related coronavirus lineages in pangolin, both of which are related to sars-cov-2 This suggests that pangolin may be a long-term host of these viruses But surprisingly, pangolin is a solitary animal with a relatively small population size and is endangered However, it can not be excluded that pangolin obtained sars-cov-2 related virus independently from bat or other animal hosts It is worth noting that both of these two kinds of pangolin coronaviruses are obtained from the smuggled Malaya pangolin, which is likely to come from Southeast Asia However, the virus diversity of this animal in the local area is obviously lack of relevant knowledge The research team believes that there is no doubt that the transmission degree of coronavirus in pangolin population needs further investigation, but the repeated infection of sars-cov-2-related coronavirus in Guangxi and Guangdong Province shows that pangolin may be an important potential host for the emergence of sars-cov-2 Coronaviruses, including those associated with sars-cov-2, are widespread in many wild mammals in Asia, the team said Although the epidemiology, pathogenicity, interspecific transmission and transmission of pangolin coronavirus still need to be studied, the data provided by this study strongly shows that the handling of these animals needs to be very careful and should be strictly prohibited from being sold on the market Further monitoring of pangolins in the natural environment of China and Southeast Asia is also necessary to understand their role in the emergence of sars-cov-2 and the risk of zoonotic transmission in the future After this paper, the rumor that "sars-cov-2 is made by people" can be stopped! Human beings should reflect on themselves! China is one of the countries with the largest outbreaks of pathogens from wild animals Each virus has its own ecosystem, so does the coronavirus It just wants to live in animals, not harm people It's not easy to find a host like pangolin and bat We have evolved together for many years, lived a good life, and have been at peace Ignorant human beings must break this balance! In the end, let's review the disappearance of SARS I hope the tragedy doesn't happen again In 2003, Professor Guan Yi's team found that civet cats tested positive earlier than the American team (12-24 hours in advance) His team was monitoring the civet cats in Guangdong market for a long time after SARS In September of the same year, he found that civet cats appeared in the wild market in Guangdong again As long as there are civets in the market, he will bring them back to the laboratory in Hong Kong, and even his wife will bring them back to Guangdong every week It is precisely because of his detection in place that several cases of positive results were found in the follow-up and showed an upward trend After comparison in the laboratory, it was found that the virus of new patients in Guangzhou was completely consistent with the animal virus samples taken after October 2003 After receiving the early warning, the Guangdong government organized the campaign to eliminate civet cats After the eradication, there were no new cases At the same time, it proves that the wild animal market is indeed the hotbed of SARS virus That's why the virus disappeared completely after SARS References: 1 'the disruption is irregular.' coronavirus environmental snarls science worldwide doi: 10.1126/science.abb3556 2 Identification of 2019 ncov related coronaviruses in Malaysia pangolins in southern China doi: 10.1101/2020.02.13.945485