The first China Encephalitis Conference opened the door of precision medicine of encephalitis to celebrate the 70th birthday of the motherland

Golden Autumn October, shengsheng China, warmly celebrate the 70th anniversary of the great motherland of the joy of the atmosphere is still continuing, once again to show the achievements of the new Chinese medical academic event - the first Chinese encephalitis conference held in the capital Beijing victoryThe 2019 China Encephalitis Conference was organized by the Professional Committee of Neuroscience of the Chinese Research Hospital Society, the Beijing Medical Association's Rare Diseases Branch, beijing Concord Hospital Neurology Branch, the Institute of Psychology of the Chinese Academy of Sciences, and was co-sponsored by the Medical Laboratory (hereinafter referred to as "Not a Laboratory"), Ormond Medical Diagnostics (China) Co., Ltd., and The Academy of SciencesThis conference, with the theme of "The Road to Precision Medicine of Encephalitis", conducted in-depth exchanges and discussions on the precise diagnosis of encephalitis, the latest research results of autoimmune encephalitis and cerebrospinal fluid sequencing, clinical cerebrospinal cytography and so onMore than 400 experts, scholars and medical colleagues from all over the country gathered to celebrate the future, discuss and exchange new developments in encephalitis, and offer suggestions for promoting the diagnosis and treatment of meninacination-related diseases, Professor Cui Liying of Beijing Concord Hospital, Chairman of the Chinese Medical Association's Neuropathy Credit Group, Professor Zhao Gang of Xijing Hospital, Honorary Chairman of the General Assembly; Professor Wang Jing, Vice Chairman of the Professional Committee of TUBERculosis Meningitis of the Chinese Medical Association's Tuberculosis Credit Association, Professor Guan Hongzhi of Beijing Concord Hospital, serves as President of the General Assembly; Professor Guan Hongzhi and Vice Chairman of the Pediatric Neurology Group of the Paediatric Branch of the Chinese Medical Association, Professor Fang Fang of Beijing Children's Hospital as Executive Chairman of the General Assembly; and Beijing Concord Hospital as Secretary-General of the General AssemblyThe opening ceremony of the conference was presided over by the President of the General Assembly, Professor Guan HongzhiAt the opening ceremony of the, Yang Yang, management consultant of the China Research Hospital Society, addressed the organizers of the CongressYang Highlighted the basic situation, development concept, work center and latest work results of the Chinese Research Hospital Society and the members of the Neuroscience Professional CommitteeYang Yang said that as a national-level society, the China Research Hospital Society currently has a special committee led by 127 experts, 340 A-level hospital member units, more than 20,000 members, including 17 academiciansThe Society to President He Zhenxi put forward "remember one center, grasp the two origin, clear three positioning, play four roles" for the development concept, adhere to the "service to national and regional health reform and development, service research-oriented hospital construction, service member units and member experts" as the centerAt present, the Institute has set up four platforms to jointly help the implementation of the "Healthy China" national strategy, to provide more services and opportunities for expertsDirector Yang Yang's speech
Then, professor Zhao Gang, Honorary Chairman of the General Assembly, addressed the General AssemblyProfessor Zhao Gang first extended a warm welcome to the experts, scholars and fellow participants and congratulated the conference on its conveningIn his speech, Professor Zhao Gang emphasized the importance of research, diagnosis and treatment of encephalitis in the form of precision medicine to neuroscience and the whole medical field, and gave examples of the outstanding achievements made by the research team in the field of national precision medicine: the national multi-center research on infectious encephalitis led by Professor Guan Hongzhi, the research of self-free encephalitis led by Professor Wang Jiawei, and the research of cancermeningitis led by Professor He Junhui, Professor Bo Wei, and the major breakthrough scored in recent yearsIt is hoped that today, with the path of precision medicine of encephalomyal (membrane) inflammation as the beginning, practical research, the future Chinese scholars can be in the field of neurology, in the international academic arena to achieve more brilliant achievements Professor Zhao Gang's speech
After the opening ceremony, the General Assembly officially entered the academic conference session, Professor Wang Jiawei as the academic moderator Professor Guan Hongzhi first made the "China Encephalitis Conference and encephalitis professional treatment center recommendation work report", and presided over the encephalitis professional diagnosis and treatment center licensing ceremony Professor Guan summarized the collaborative research on encephalitis conducted by the Professional Committee of Neuroscience and the Collaboration Group of Encephalitis in China's Research Hospital Society, the recommendation and selection of the professional treatment center for encephalitis, and the preparation and submission of the encephalitis conference The professional treatment center for encephalitis has received a positive response from the national medical units, with a total of 106 units running and 43 units selected Director Yang Yang, Professor Wang Jiawei, Professor Guan Hongzhi, Deputy Head of the Infectious Diseases and Cerebrospinal Fluids Group of the Chinese Medical Association's Neurology CreditS, Professor He Junhui of the Second Hospital of Hebei Medical University, and Mr Li Chuan, founder of the Academy, jointly awarded the license to the selected units, thanking the units for the improvement of the clinical diagnosis and treatment of encephalitis disease, and making positive contributions to the scientific and academic research work of encephalitis After the licensing ceremony , Professor Guan Hongzhi made a wonderful speech on the precision medicine of Chinese encephalitis, which focused on the history of the development of Chinese encephalitis research, in which the anti-neuroantibody spectrum, which has been expanding with the development of laboratory diagnostic technology, has significantly promoted the progress of the discipline He pointed out that "China's autoimmune encephalitis diagnosis and treatment expert consensus" (Guan Hongzhi, Wang Jiawei) is an important reference for the standardized diagnosis and treatment of encephalitis Professor Guan then introduced a series of multi-center and single-center research results published by the National Encephalitis Collaboration Group, and pointed out that China has been in the international leading level in the second generation sequencing research and clinical application of cerebrospinal fluid genome Finally, Professor Guan pointed out that the standardization, individualization and specialization of encephalitis diagnosis and treatment is the future direction of development Professor Guan Hongzhi spoke
Professor Wang Jiawei made a wonderful speech entitled "Antibody-related inflammatory demyelinology and astromycollocytes disease", which introduced in detail the mesothelial neurology, demyelinating disease, autoimmune encephalitis, glial cell disease represented by anti-GFAP antibodies, and antibody overlap syndrome In the field of demyelinator disease, the results of a study of 415 cases of optic neuritis at Tongren Hospital in Beijing showed that the positive rates of AQP4 antibodies and MOG antibodies were 13.5% and 6.7%, respectively In the field of autoimmune encephalitis, the task force is responsible for the Ministry of Science and Technology national key research and development plan - autoimmune encephalitis molecular type study, a total of more than 11,700 samples screened, the positive rate of 12.1% More and more research results show that the field is developing rapidly, the discovery of related antibodies has redefined the subtype of disease, antibody detection is of great significance to the diagnosis and treatment of diseases Professor Wang Jiawei Big Data offers more possibilities for the development of modern medicine, and deep learning and artificial intelligence will also provide new contributions to the progress of disease diagnosis and treatment Professor Wang Jing made a distinguished speech on the theme of Disease Research and Medical Applications in the Age of Big Data Professor Wang Jing put forward the wide application of big data and the development of bioinformatics technology is a necessary prerequisite and core driving force for the transformation of medical model to "precision medicine" The disease research in the age of big data faces many challenges, including massive data, multidimensional, multi-dimensional, high heterogeneity, which requires us to integrate and system mining of multi-dimensional data The "integrated" strategy of disease research is the future direction of development, and multi-group and clinical data together constitute "systemic medicine" Taking brain disease as an example, it is necessary to integrate multi-dimensional data such as behavior and environment, imaging, molecular biology, and so on, so that the combination of big data and artificial intelligence can provide strong support for medical decision-making in the future Professor Wang Jing Professor Chen Weijun of the University of the Chinese Academy of Sciences made a speech on "The Application and Norms of Macrogenomics Technology in Difficult Infectious Diseases", Professor Chen pointed out that macrogenomic technology can effectively improve the etiology diagnosis of unexplained infectioncompared with traditional technology, and that macro-genome sequencing of cerebrospinal fluid is playing an increasingly important role in the diagnosis of infectious encephalomyritis Professor Chen also gave detailed advice on how to use clinical-grade macro genome detection products Professor Chen Weijun, said
The unknown virus in nature may be far beyond our imagination Macrogenomics (especially macrotranscriptiography) can help us discover new microbiomes such as viruses, bacteria, parasites, etc Dr Xincheng Zhang, from the Infectious Disease Prevention and Control Institute of the Chinese Center for Disease Control and Prevention, introduced a series of important research results made by the research team in the past 5 years on RNA virus through a report entitled "Integrated Technology for the Diagnosis of ClinicalLy Infected Pathogens - Macro Transcriptoon Technology", which laid the foundation for the discovery of Alongshan viral encephalitis in 2019 The discovery of a large number of new viruses has changed human understanding of the virus community, but also has important public health significance, for potential new pathogens, we need to do: early detection, early identification, early analysis, early warning, active defense, precision prevention and control! Dr Yu Xincheng spoke In the main forum of this conference, special focus on the integration of encephalitis precision diagnosis program, and held a project start-up meeting, for 15 research units issued certificates Mr Ren Haitao, Dr Fan Siyuan and Dr Li Wenhan of the Non-Lab signed a speech at the seminar Beijing Concord Hospital Neurology Laboratory is the first to carry out the laboratory work of autoimmune encephalitis antibody spectrum, and published a number of high-quality related articles, reported a number of domestic first cases, including anti-IgLON5 encephaliand and rare types of antibody-related autoimmune encephalitis, etc., to make a positive contribution to the continuous optimization of autoimmune encephalitis antibody spectrum Mr Ren Haitao, head of the immunology program of the Neurology Laboratory of Beijing Concord Hospital, introduced the clinical diagnostic significance of the above antibodies and emphasized the importance of the use of a rigorously controlled commoditized kit for the identification of rare antibodies, as well as the tbA verification experiment, through a wonderful report entitled "Encephalitis Integration: Comprehensive Testing Program for Autoimmune Encephalitis Antibody Genealogy" Recommended serum and cerebrospinal fluid testing at the same time, wherein anti-NMDAR antibodies to cerebrospinal fluid positive, anti-GAD65 antibodies to serum and cerebrospinal fluid at the same time positive or cerebrospinal fluid positive, anti-LGI1, GABABR and other antibodies to serum, antiCASPR2 antibody recommended cut-off value of 1:32 Ren Haitao teacher spoke Dr Fan Siyuan to do "Encephalitis integration: cerebrospinal fluid second-generation sequencing clinical indications and results interpretation" speech, Dr Fan proposed that cerebrospinal fluid second-generation sequencing of the indications include: CNS infection, such as encephalitis (including encephalomyelitis), meningitis, is chronic / recurrent meningitis, chronic encephalitis first-line examination, acute encephalitis, disease meningitis quasi-first line examination The team put forward the current standard of cerebrospinal fluid second-generation sequencing interpretation under the current information volume: the result classification uses three-point method: positive, suspicious positive and negative; The number of SSRN is sufficient; 2 Pathogens are in the top 10, indicating that sample contamination may or may not be of poor quality if there are many other background bacteria; and 3 If 1/4 of the same sample sit in the same sample, it suggests cross contamination Suspicious positive results help to expand the idea of differential diagnosis and further verify the results in the light of clinical conditions Dr Fan Siyuan spoke
And then Dr Li Wenhan of a medical laboratory made a wonderful academic speech entitled "Integrated Process of Precision Diagnosis of Encephalitis" The etiology of encephalomyal inflammation includes infection and self-exemption, both clinical manifestations and even routine examination are highly similar, and it is urgent to support clinical decision-making by directly etiologically oriented testing programs Dr Li Wenhan introduced the integrated process of the etiology of encephalitis in the precise diagnosis application of the disease-oriented integrated laboratory diagnostic strategy in the laboratory In the aspect of autoimmune encephalitis (AE), not only is the first laboratory in China to provide comprehensive autocyantibody spectrum testing, but also the only third-party laboratory in China to carry out joint CBA and TBA testing, laboratory data examples prove that the joint detection of CBA and TBA for the identification of target antigens, especially the screening of non-specific results The large sample data of more than 20,000 cases in one laboratory is an important epidemiological reference for Chinese group AE, which indicates the presence of double antibody positive, but very rare Detection of the infectious cause of encephalomyal inflammation, the first macro genomic technology The Acer project in no laboratory uses a comprehensive and efficient detection strategy to ensure detection sensitivity and data volume, a more targeted database, and a rigorous and standardized quality system and quality control to ensure data quality and reporting quality Dr Li Wenhan spoke the final launch meeting, by Professor Guan Hongzhi, Ren Haitao teacher, Dr Li Wenhan jointly issued certificates for the participating units Encephalitis Integrated Diagnostic Process Research Center Launch Ceremony
In order to promote the development of encephalitis-related diseases diagnosis and improve the level of diagnosis and treatment of specialized diseases, the conference also set up 6 thematic forums, respectively, around the "precision diagnosis of neuroinfectious diseases" "Clinical cerebrospinal cell science seminar (CCCC 2019)" "neuroimmune and The six topics of neuritis diseases "encephalitis and genetic metabolic diseases" "paediatric neuro-infection immunity" "encephalitis and cognitive mental disorders" have been conducted in various forms and rich levels of academic exchanges and discussions, and the sub-forums have deepened their understanding and understanding of encephalitis-related diseases through thematic speeches, papers and case discussions Forum on-site interaction, frequent questions, we for all kinds of encephalitis diagnosis methods, strategies and clinical common problems have been actively and eagerly exchanged (Sub-forum excellent academic report content, please follow-up report) During the meeting, the Expert Group of the General Assembly also carried out a wall presentation and evaluation of the outstanding papers collected, and presented awards for outstanding papers and outstanding wall newspapers at the closing ceremony of the Conference The conference included 246 papers from 26 provinces, autonomous regions, municipalities and special administrative regions, including 93 research papers, 137 case reports, and 16 cases from clinical cerebrospinal cellology (Clinical CSF Cytology Conference, CCCC) during a month's draft Among them, a total of 19 selected speech exchange, 48 wall newspaper exchanges, covering nerve infection, immunity, bioinformatics, pathogen macro genomics technology, disease prevention and control, encephalitis psychopsychology, basic medical research and other fields These academic papers focus on the recent research results of Chinese encephalitis majors, reflecting the attention and input of encephalitis research The conference finally selected a total of 45 outstanding papers and outstanding wall newspapers, and issued award certificates 2019 Encephalitis Conference is an important academic event in the field of neurology in China, which provides a high-quality communication, display and learning platform for neurology in China, especially in the field of encephalitis-related diseases The conference, which made 44 speeches and attended more than 400 participants, achieved great success in both scale and quality, and as the first encephalitis conference, it laid a good foundation and a good start for the future session the conference