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With the global launch of the new crown vaccination campaign, the new crown epidemic in some countries and regions has gradually been brought under control

Recently, Nature Medicine, a subsidiary of Nature, revealed an extremely rare adverse event caused by Pfizer/BioNTech's new crown mRNA vaccine BNT162b2

Cytokine storm, or cytokine release syndrome (CRS), is a "random killing" of the immune system triggered by severe stimuli such as bacteria and viruses, which manifests itself as a systemic inflammatory response

The protagonist in this report is a 58-year-old male who has been receiving anti-PD-1 treatment for colorectal cancer since February 2019.

Five days after vaccination, that is, 32 days after receiving anti-PD-1 treatment, the patient began to develop symptoms of fever, diarrhea, and muscle aches.

In the next 5 days, the patient's condition deteriorated, his body temperature reached 39.

Based on these data, the medical staff speculated that this patient may be suffering from CRS (level 3), so he was given intravenous methylprednisolone (IVMP) starting from January 1, 2021, and the patient’s biochemical and blood tests 7 days later The academic indicators returned to normal levels

On February 8, 2021, this patient resumed anti-PD-1 therapy, and no adverse effects were observed clinically

In short, this report shows that anti-PD-1 drugs may be a potential factor that causes cancer patients to cause CRS after being vaccinated with the new crown vaccine