The first male contraceptive pill is coming soon.

Will the birth of RISUG, the world's first injectable male contraceptive pill, be a boon for women? Does it herald a new era of contraception? In primitive times, the concept of "contraception" was not fully developed, but there was already contraception.
some women use some intense exercise to promote sperm removal in the body to achieve contraceptive effects.
greek doctors in the 2nd century had advised Greek women to jump seven times in the same room to use contraception.
some women in Europe would take a "more reliable approach" and push back and forth four times in the second half of the night as doctors recommended... In ancient Greece and Egypt, the concept of sex changed, so that people need something to pursue sexual freedom, the emergence of contraceptive technology is meeting this demand.
this case, people use mint plants, seeds from wild carrots, silky oil paper, cloth dough, sponges stuffed into women's bodies, and drink graphite or mercury for contraception.
the advance of civilization has led to a constant change in contraceptive methods, and in modern times there are already a variety of contraceptive methods, including IDR, insulate implants, female/male sterilization, oral contraceptives, etc.
The National Health Board's 2018 Overview of Common Contraceptive Methods notes that contraception includes both efficient and non-efficient methods of contraception, with dozens of common methods targeted at women and only male sterilization and male condoms.
recently, the Indian Daily and other authoritative media reported that the Indian Medical Research Council has completed the first injection of male contraceptive pill RISUG clinical trials.
has now been submitted to the Indian Drug Administration for approval.
303 male volunteers were recruited for the study, and all the test results completed showed a 97.3 percent success rate for RISUG contraception, with no adverse reactions detected, said Sharma, who led the research project.
india's report on the first male contraceptive pill (Photo: The Times of India) has attracted global attention.
can the male contraceptive pill be widely popularized and applied on a global scale? Can the broad female population be liberated by contraception? Will the birth of male contraceptives change the status quo of contraception in china? Contraceptives to the female body harm can not be underestimated despite the continuous development of contraceptive methods, for a long time, the general concept of people often think that contraception is a woman's thing, is a woman's "task."
ancient methods of contraception can do harm to a woman's body, and the words "intense exercise, repeated jumping, oil paper, cloth dough, graphite, mercury" alone are enough to make people feel the same way.
Deng Chunhua, chairman of the Men's Science Branch of the Chinese Medical Association and director of the Men's Section of the First Hospital affiliated with Zhongshan University, has pointed out that female contraceptive pills may cause women to experience dizziness and nausea, endocrine disorders, and irregular menstrual cycles in women, which have a certain impact on their physical health.
Du Yixin, director of obstetrics and gynecology at the Second People's Hospital of Hunan Province, has also said that oral contraceptives, simple progesterone contraceptives, under-skin implantation methods, IUD and other methods of contraception may cause women to experience increased menstrual volume and bleeding after use, especially the use of IUD, may appear uterine perforation and other conditions.
pregnancy is an important global health risk event with a wide range of social, health and economic implications.
unplanned pregnancies often lead to abortion.
, there are about 85 million unwanted pregnancies worldwide each year, of which 50 percent end in abortion, resulting in about 40-60 million abortions per year.
the low rate of high-efficiency contraception among women in China, the low awareness of high-efficiency methods of contraception, the abortion rate remains high, with about 9.6 million cases per year.
abortion can damage a woman's endometrium and potentially harm the reproductive system and its function.
Among the commonly used contraceptive methods recommended by the National Health Council, the probability of unwanted pregnancies in women after the first year of use is mostly no more than 1 person/100 years for women, while the probability of unwanted pregnancies in male contraceptive methods after the first year of use is 29/100 years for women, which is much higher than the rate of unwanted pregnancies by female contraceptive methods.
Despite the hundreds of years of development and variety of contraception among women, they are very effective in preventing unwanted pregnancies, and it is necessary to explore appropriate, high-contraceptive male contraceptive methods, given that common methods of contraception are currently more effective for women.
Common methods of contraception use the first year of unsympathetic pregnancy rate hormone inhibition of "small slugs" to form effective contraception Despite the need to explore more efficient male contraceptive methods, more than 50 years of research on male contraceptive methods has not been able to obtain effective and feasible male contraceptive treatment.
addition to sterilization and condoms, male contraception is mainly male hormonal contraception and male non-hormonal contraception.
male hormonal contraception works through the normal regulated hormone formation and sperm formation of the hypothyroid brain-pituitary gland feedback circuit.
glandular hormone release hormone (GnRH) released by the hypothyroids triggers the release of progesterone (LH) and follicle hormone (FSH) in the pituitary gland.
in normal healthy men, LH binds to androgens on testicular interstate cells to stimulate hormone production, mainly testosterone production.
FSH is combined with the support cells in the small tube to further stimulate sperm formation.
testosterone spreads from the testicles to the body circulation, providing negative feedback at both the lower hem and pituitary levels.
Normal male hypothyroid-pituitary gland feedback circuit Men who take testosterone for a long time can inhibit the release of pituitary LH and FSH through this hypotheroid-pituitary gland feedback loop, testicular sperm production is inhibited, playing the role of male contraception.
3-6 months after most men stop using testosterone, sperm can return to pre-hormone levels.
negative feedback mechanism for male hormonal contraception normal men have between 0.15 and 150 million sperm per milliliter of semen.
when the sperm concentration per milliliter of semen is less than 1 million, the probability of pregnancy is reduced to less than 1%.
, achieving a full sperm content reduction to 1 million/ml of semen will be the ultimate goal of male contraceptives.
hormonal contraceptives, which are not effective because they degrade quickly by the liver after oral or gastrointestinal use, are mostly given by intramuscular injection. More than
studies have shown that after regular intramuscular injections of 200 mg of testosterone tetrate to hundreds of subjects for a certain period of time, the overall failure rate is low, the contraceptive effect is more than 96%, testosterone-induced insemination is a very effective method of contraception.
And in these studies, after stopping the injection of hormones, the subject's sperm levels gradually returned to normal, and there were no major adverse reactions, it can be considered that testosterone as a male contraceptive method of high effectiveness, small adverse reactions, can be widely promoted.
male birth control pill is expected to be a female "rescue" because male hormonal contraceptive pills affect male hormone levels, some men have hormonal contraceptives will damage reproductive function of the fear and do not want to use hormonal contraceptives.
this involves another contraceptive pill, the male non-hormonal pill.
these pills do not involve changes in hormone levels, avoid any effects on sexual function, and may be more attractive to men.
at the beginning of the article, RISUG is a male non-hormonal contraceptive.
RISUG works by injecting a non-toxic polymer gel into a male vasectomy tube, and after a few minutes the gel forms a transparent coating on the wall of the vasectomy tube, destroying the polymer surface electrode in the gel (the chemical contained in the gel is destructive to the outer membrane of the sperm), and hundreds of millions of sperm will lose their vitality and fail to "go out" smoothly, thus giving effect to contraception.
risug researchers note that the polymer does not affect male sex hormone levels and has few adverse reactions.
is valid for up to 13 years and is reversible.
the gel is dissolved through a 10-use solvent DMSO, sperm can also function normally.
RUSUG, researchers have been studying different non-hormonal contraceptives for decades.
Such as Adjudin can destroy sperm cell adhesion to supporting cells, leading to premature sperm fertilization and infertility; H2-Gamendazole can damage the function of top exosome specialization; Eppin protein small molecule inhibitors can reduce the secretion of semen protein Eppin, the effect of contraception; small molecule JQ1 can inhibit BRT protein function to inhibit sperm production; retinic acid inhibitor pan-antagonists can reduce sperm production and so on.
But the study of these non-hormonal contraceptives may have significant adverse reactions, or the cost is too high, or the research is still at an early stage, or the drug is not specific and still needs to go through a lot of work before it is actually visible.
However, these findings also give us confidence that more male contraceptives will be possible, and that more effective male contraceptives will emerge in the future through more animal and clinical trials, so that efficient and safe contraception can be achieved, making contraception a shared responsibility for both men and women.
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