The first molecular map describing the development of the human cerebellum

The first molecular map describing the development of the human cerebellum

The first to describe the creation of a molecular map of human cerebellar development The first to describe the creation of a molecular map of human cerebellar development

Science and Technology Daily, Beijing, July 15 (intern reporter Zhang Jiaxin) According to a paper recently published in "Nature Neuroscience", researchers from the Seattle Children’s Institute in the United States described the space and cell types of cerebellar development in detail for the first time, aiming to improve Have a good understanding of the development of the human cerebellum
.

The cerebellum is the main structure of the back of the human brain, which is essential for the realization of several motor functions, as well as cognition, emotion regulation and language processing
.

However, compared with the cerebral cortex, there are still relatively few studies on this structure, and little is known about its development process over time

Researcher Dr.
Kimberly Aldinger and others used a single-cell transcriptome sequencing technology developed by researchers at the University of Washington in the United States, which can classify and track different types of cells in tissue samples
.

Using this technology and laser capture technology to achieve the microdissection of spatially defined progenitor cell regions, the team can specifically capture the transcriptome of all developing cerebellar cell types, including the very rare ones present in the developing human cerebellum Cell

Researcher Dr.
Catherine Mirren said that before, many models of human cerebellar development and diseases were based on mouse-centric data
.

There was no data on the development of the human cerebellum, but we now know that the development of the human cerebellum is very different from that of the mouse

"We have produced the first comprehensive molecular map of cell types and gene expression during human cerebellar development
.

This is a rich resource for the scientific community to explore the genetic programs that promote human cerebellar development and the origin of diseases

It is understood that the first batch of molecular data describing the development of the human cerebellum collected by researchers can now be shared by other scientists around the world, or will help the scientific and medical communities to better understand the causes of neurodevelopmental disorders affecting the cerebellum, such as Congenital malformations, autism, and childhood cerebellar cancer
.

According to the researchers, they still lack molecular data on the early time points of the birth of several important cerebellar cells, as well as data linking developmental time points with mature adult cell types
.

In order to better define the mechanisms that drive the size and differentiation of progenitor cells, they are conducting in-depth data mining