echemi logo
Product
  • Product
  • Supplier
  • Inquiry
    Home > Biochemistry News > Biotechnology News > The first pig kidney transplanted into a human body, what do scientists think?

    The first pig kidney transplanted into a human body, what do scientists think?

    • Last Update: 2022-08-15
    • Source: Internet
    • Author: User
    Search more information of high quality chemicals, good prices and reliable suppliers, visit www.echemi.com


    The team that conducted the experiment reported that kidneys from genetically engineered pigs with human-like immune systems functioned successfully when transplanted into two recently deceased patien.


    Researchers transplanting pig organs into non-human primates have had great success: A baboon survived for more than two years with the help of a genetically modified pig hea.


    Montgomery and his colleagues conducted transplant trials in September and November 2021 using pigs genetically engineered to lack a gene called alpha-1,3-galactosyltransferase (αGa.


    They tested these "thymic kidneys" on two people who had been declared legally dead a day or two before because they had no brain functi.



    In a paper published May 19 in The New England Journal of Medicine, the researchers said patients did not have an immediate immune response to these orga.


    genetic modification

    However, other researchers are skeptical of the resul.


    In addition, it was difficult to tell whether the pig's kidneys were at work, or whether the urine and creatinine actually came from the patient's own kidne.


    Like Montgomery's team, Porrett's team had little immune response to the org.


    ethical issues

    Cooper was not surprised by the findings of the two research groups: Studies of baboon and human serum have shown that the primate immune system does not immediately reject alphaGal-deficient pig orga.


    Montgomery and Porrett said extending the experiment may be medically feasible, as some patients survive for months after being declared brain de.


    But doing so for research purposes raises ethical concerns because patients' remains should be handed over to their families as soon as possible, said Rebecca Pentz, a bioethicist at Emory University in Atlan.


    However, Penz said the NYU study followed the rules set by the researchers' ethics committ.


    heart transplant

    Partly because of these limitations, Cooper and others believe it's time to start transplanting animal organs into living people -- and that's only partially successf.


    The man died two months lat.


    Porett noted that the infection has not been detected in live pigs, and it is unclear whether other latent animal viruses will begin to affect humans long after transplantati.

    "We can't answer that question until we can follow patients for months or years," she sa.

    Porett and Cooper's team is applying to the.


    Food and Drug Administration for a small clinical trial of transplanting genetically modified pig kidneys into human patien.

    The kidney is the ideal starting organ because, unlike the heart, if something goes wrong, the kidney can be removed and the patient can be put on dialysis, Cooper sa.

    "It should be done with caution," he sa.

    This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.

    Contact Us

    The source of this page with content of products and services is from Internet, which doesn't represent ECHEMI's opinion. If you have any queries, please write to service@echemi.com. It will be replied within 5 days.

    Moreover, if you find any instances of plagiarism from the page, please send email to service@echemi.com with relevant evidence.