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    Home > Medical News > Medical World News > The first thymus tissue map successfully drew the human body "Google map" and further!

    The first thymus tissue map successfully drew the human body "Google map" and further!

    • Last Update: 2020-02-24
    • Source: Internet
    • Author: User
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    The thymus is the organ responsible for the maturation of many types of T cells, which are the immune system that protects us from infection Thymus is the largest and most active thymus in childhood It will gradually shrink with the growth of youth, and almost disappear at the age of 35 Understanding the development of thymus can help us to reveal aging and the changes of immune system in life Part of human thymus On February 21, researchers from the Wellcome Sanger Institute in the UK, the University of Newcastle and the University of Ghent in Belgium announced that they had successfully mapped the first thymus tissue life cycle, opening the door to new therapies for cancer and autoimmune diseases The related research results were published in science under the title of "a cell Atlas of human thermal development definitions T cell repertoire formation" DOI: 10.1126/science.aay3224 Specifically, the researchers used single cell RNA sequencing (scrna SEQ) to analyze 200000 cells from thymus of embryo, infant and adult, and identified more than 50 different thymocyte states based on gene expression results The abundance and gene expression profile of human thymocytes changed dynamically in the whole development process, as well as in childhood and adulthood At the same time, the team identified new subpopulations of human thymic fibroblasts and epithelial cells Based on the marker genes obtained from the single cell transcriptome, the researchers used single molecule fluorescence in situ hybridization (smfish) to locate new cell subsets in space In addition, they used computational methods to predict the trajectory of human T-cell development, including differentiation from early hematopoietic progenitor cells in the fetal liver to a variety of mature T-cell types Construction of human thymocyte map Professor muzlifah Haniffa, a senior clinical researcher at the University of Newcastle and Wellcome Sanger Institute, who is the co-author of the article, said: "through the thymocyte map, we can explain the cell signal information of the developing thymus, and explore the genes that need to be activated to transform early immune precursor cells into specific T cells This discovery can be used as a reference map in the future to find the most correct treatment for T cells to attack and kill specific tumors " "Human thymus map" is part of the "human cell map program" launched in 2016 to promote a deeper understanding of human health and disease " Dr Sarah TEICHMANN of the Organizing Committee of the human cell mapping program and the Wellcome Sanger Institute said, "the latest results help us to understand the development pathway in the body and explain the reasons for the age-related decline of the immune system, which provides the possibility for regenerative medicine to manufacture artificial thoracic glands." reference material: [1] Thymus atlas could spark new treatments for cancer, autoimmune disease [2] Origins of immune system mapped, opening doors for new cancer immunotherapies
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