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The first yew genome map reveals the genetic basis of paclitaxel synthesis |
Features of Taxus chinensis genome map courtesy of Institute of Genomics, Chinese Academy of Agricultural Sciences
Features of Taxus chinensis genome map courtesy of Institute of Genomics, Chinese Academy of Agricultural SciencesOn April 30th, Hunan Agricultural University and the Institute of Agricultural Genomics of the Chinese Academy of Agricultural Sciences (hereinafter referred to as the Institute of Genomics) and other units jointly published the world's first yew reference genome map on the preprint platform bioRxiv, and revealed that yew has synthesized anticancer drugs The genetic basis of paclitaxel.
Taxus chinensis has been designated as a first-class rare and endangered plant in my country, and it is also called "national treasure" by 42 countries in the world that have yew.
Yan Jianbin, co-corresponding author of the paper and a researcher at the Institute of Genomics, introduced that they successfully assembled a chromosome-level high-quality reference genome by sequencing the whole genome of the haplotype endosperm material of Taxus chinensis.
The study found that the size of the Taxus chinensis genome is 10.
According to Xiong Xingyao, the co-first author of the paper, studies have shown that the yew genome has undergone an ancient whole-gene duplication event, and the repetitive sequences in its genome have undergone a long-term and continuous insertion process.
They systematically analyzed the genomic location and coordinated expression regulation of genes related to paclitaxel synthesis, and mapped the genomic location of multiple related gene families, particularly revealing the genomic distribution and regulation of the cytochrome P450 family.
The study discovered for the first time the aggregation and distribution of paclitaxel synthesis genes on yew chromosome 9 and identified the first paclitaxel biosynthesis gene cluster, which consists of six genes in tandem, and is mainly responsible for catalyzing the first two steps of paclitaxel biosynthesis.
This research is a major breakthrough in the field of taxol and paclitaxel.
The research has been supported by the National Key Research and Development Program, the Special Program for Basic Scientific Research of China’s Agriculture, the Young Talent Program of the Chinese Academy of Agricultural Sciences and the Innovation Project of the Chinese Academy of Agricultural Sciences, the Scientific Research Fund of the Education Department of Hunan Province, and the “Double First Class” construction of Hunan Agricultural University.
Related paper information: org/10.
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1101/2021.
04.
29.
441981" target="_blank">https://doi.
org/10.
1101/2021.
04.
29.
441981