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    Home > Food News > Food Articles > The Food and Medicine Homologous Functional Food Team of Yunnan Agricultural University: α-linolenic acid promotes the proliferation of mouse intestinal stem cells by regulating the intestinal flora

    The Food and Medicine Homologous Functional Food Team of Yunnan Agricultural University: α-linolenic acid promotes the proliferation of mouse intestinal stem cells by regulating the intestinal flora

    • Last Update: 2022-01-07
    • Source: Internet
    • Author: User
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    Editor in charge: Food Science

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    Recently, the team of Professor Sheng Jun and Professor Tian Yang of Yunnan Agricultural University published an online cover paper "Short-chain fatty acids produced by Ruminococcaceae mediates α -Linolenic acid promote intestinal stem " in the international authoritative journal Molecular Nutrition & Food Research (IF=5.
    914, TOP journal)
    cells proliferation .
    Studies have revealed the role and mechanism of α -linolenic acid by increasing the abundance of rumen cocci microbes, increasing the content of short-chain fatty acids, and activating the Wnt/ β- catenin signaling pathway, thereby promoting the proliferation of intestinal stem cells .
    In addition, α -linolenic acid promotes the proliferation of intestinal stem cells, improves the intestinal barrier, and relieves 5-fluorouracil-induced intestinal mucositis .
    These results provide a scientific basis for the application of α -linolenic acid in the prevention and treatment of intestinal mucositis .




    Intestinal epithelium is the fastest renewal tissue in adult mammals, and it plays an important role in nutrient absorption, hormone release, and immune barrier function
    .
    The continuous renewal of intestinal epithelial cells is essential for maintaining the normal structure and function of the intestinal mucosa, and the driving force for this renewal comes from the proliferation and differentiation of intestinal stem cells (ISCs)

    .

    Intestinal microbes play a key role in regulating the homeostasis and integrity of the intestine, and shaping the various morphological and functional characteristics of different intestinal regions and different intestinal cell subgroups
    .
    Current studies have confirmed that gut microbes can directly or indirectly regulate the proliferation and differentiation of ISCs through pattern recognition receptors, multiple signaling pathways, and metabolites

    .
    Among them, intestinal microbes can participate in the regulation of ISCs by activating the Wnt signaling pathway, and short-chain fatty acids (SCFAs), the metabolites of intestinal microbes, can regulate the proliferation and differentiation of ISCs

    .


    Dietary nutrition has the effect of regulating the proliferation and differentiation of ISCs, while strongly affecting the morphology and function of intestinal epithelial cells
    .
    For example, high-fat diet, calorie restriction, fasting, zinc, vitamin D3, glutamine, etc.
    , can regulate the activity of ISCs and change the length of the small intestine and villi

    .
    Among them, fatty acids in a high-fat diet, including palmitic acid, oleic acid and lipid mixtures, have the function of driving the self-renewal of intestinal organoids and inducing the proliferation of epithelial cells

    .
    However, it is still unclear whether
    α -linolenic acid (ALA), one of the essential fatty acids in the human body, can promote the proliferation of ISCs
    .
    Therefore, the purpose of this study is to explore the role of ALA in promoting the proliferation of ISCs, and to reveal the mechanism of ALA promoting the proliferation of ISCs through the intestinal microbe-metabolite-signaling pathway axis

    .

    The study found that ALA promotes the proliferation of ISCs by activating the Wnt/ β- catenin signaling pathway, which in turn promotes the growth of the small intestine and villi of mice
    .
    At the same time, ALA increased the abundance of Rumencoccaceae and Prevobacteriaceae, and promoted the production of SCFAs

    .
    Subsequent fecal bacteria transplantation experiments and antibiotic intervention experiments showed that the effect of ALA in promoting the proliferation of ISCs depends on the intestinal microbes, and the functional flora is related to the rumen cocci microbes

    .
    The microbial metabolite isobutyrate promotes the proliferation of ISCs by activating the Wnt/
    β- catenin signaling pathway
    .
    In addition, ALA promotes the proliferation of ISCs, improves the intestinal barrier, and reduces the intestinal mucosal damage caused by 5-fluorouracil

    .
    These results indicate that SCFAs produced by Rumenococcus microorganisms mediate ALA to promote the proliferation of ISCs by activating the Wnt/
    β- catenin signaling pathway, suggesting the possibility of ALA as a prebiotic for the prevention and treatment of intestinal mucositis
    .



    Figure 1 Abstract of the article illustration

    Corresponding author profile



    Professor Sheng Jun

    Sheng Jun, PhD, Professor, PhD supervisor
    .
    Mainly engaged in biotechnology research and development

    .
    Undertook 1 national 863 project, more than 10 national, provincial and ministerial level projects, applied for more than 40 international and domestic invention patents, obtained 10 national invention patents, and published more than 200 papers

    .
    Won the 2017 Yunnan Province Science and Technology Progress Special Award, the 2018 Yunnan Province Science and Technology Outstanding Contribution Award, and the 2019 Yunnan Province Science and Technology Progress Award first prize

    .
    He was once selected as the "China Outstanding Youth Science and Technology Innovation Award", the first batch of national candidates for the "Cross-century Hundreds, Thousands of Talents Project", and the first batch of "100 Overseas High-level Talents" introduced by Yunnan Province

    .
    He was named "National Outstanding Scientific and Technological Worker" in 2010, and was awarded the title of "Yunling Scholar" in 2014

    .
    He also serves as the vice chairman of the Chinese Society of Microbiology, the review expert of the National Science and Technology Progress Award, and the new drug review expert of the State Food and Drug Administration

    .




    Professor Tian Yang

    Tian Yang, PhD, Professor, PhD supervisor
    .
    He is currently the Dean of the School of Food Science and Technology of Yunnan Agricultural University, the director of the Engineering Research Center for the Development and Utilization of Food and Medicine Homogeneous Resources, the Director of the National Moringa Processing Technology Research and Development Professional Center, and the director of the Yunnan Medicine and Food Homogeneous Functional Food Engineering Research Center

    .
    Leading talents in industrial technology in Yunnan Province, and reserve talents for young and middle-aged academic and technical leaders in Yunnan Province

    .
    Yunnan Province Food and Medicine Homologous Functional Food Master Mentor Team

    .

    Mainly engaged in the research of food and medicine homologous functional food
    .
    Presided over more than 10 national, provincial and ministerial scientific research projects; published more than 120 academic papers, published 21 SCI papers as the first or corresponding author (IF≥10, 1 paper; IF≥5, 7 papers), authorized 38 national patents 4; 4 national and industry standards were formulated; 4 works by editor-in-chief or associate editor; 1 first prize of Yunnan Province Science and Technology Progress Award, 2 third prizes; 1 third prize of Liangxi Forestry Science and Technology Progress Award

    .
    He is also a director of the Chinese Society of Food Science and Technology, a director of the National Food and Drug Co-sponsored Science and Technology Innovation Alliance, and a member of the Youth Working Committee of the National Agricultural Products Processing Technology Research and Development System

    .



    Editor: Yuan Yi; Editor in charge: Zhang Ruimei

    The article, author's introduction and pictures are from the Food and Medicine Homologous Functional Food Team of Yunnan Agricultural University.
    Click
    https://onlinelibrary.
    wiley.
    com/doi/10.
    1002/mnfr.
    2.
    .
    .
    to view the original English abstract
    .

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