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    Home > Food News > Food Articles > The food nutrition and functional food team of the Institute of Agricultural Products Processing, Chinese Academy of Agricultural Sciences revealed that FIP-nha-fungal immunomodulatory protein induces human gastric cancer

    The food nutrition and functional food team of the Institute of Agricultural Products Processing, Chinese Academy of Agricultural Sciences revealed that FIP-nha-fungal immunomodulatory protein induces human gastric cancer

    • Last Update: 2022-05-08
    • Source: Internet
    • Author: User
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    Responsible Editor: Food Science

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    Gastric cancer is a common malignant tumor
    .
    In China, the incidence and mortality of gastric cancer ranks second among various diseases

    .
    Chemotherapy has been proven to be helpful in the treatment of gastric cancer, however, existing chemotherapeutic drugs are prone to cytotoxicity and drug resistance

    .
    Therefore, finding pure natural anticancer materials with homology of food and medicine and exploring their role in the prevention and treatment of gastric cancer have become the current research hotspot
    .
    Fungal immunomodulatory proteins (FIPs) are a class of small-molecule proteins first discovered in edible fungi , which can exert dual anticancer effects by activating the immune system and directly acting on tumor cells .

      FIP-nha is a new type of FIP first discovered in the ascomycete Nectria haematococca by gene mining
    .
    The team's previous anti-cancer spectrum screening found that FIP-nha showed high selectivity for gastric cancer cells, but the molecular mechanism of FIP-nha's inhibition of gastric cancer cell proliferation is still unclear

    .
    On this basis, this study used human gastric cancer cell lines AGS and SGC7901 as model cells to explore the systemic antitumor effect and mechanism of recombinantly expressed FIP-nha

    .

      The results show that FIP-nha can significantly inhibit the proliferation of AGS and SGC7901 in a time- and concentration-dependent manner, but has almost no toxic effect on normal cells; FIP-nha can both promote apoptosis and autophagy in two gastric cancer cells; in-depth Mechanism exploration confirmed that FIP-nha competes with EGF to bind EGFR, thereby reducing the activation effect of EGF on EGFR and its downstream signaling molecules STAT3 and Akt; The cell surface structure of the transmembrane protein EGFR is bound by hydrogen bonds and van der Waals forces
    .
    This study systematically studied the anti-gastric cancer effect, molecular mechanism and target of FIP-nha for the first time, laying a theoretical foundation for the development of FIP-nha as a new functional product and target drug targeting EGFR in the treatment of human gastric cancer

    .

      The research was recently published in Food Chemistry: Molecular Sciences (IF 7.
    514), an internationally renowned academic journal in the field of food

    .
    Associate researcher Li Shuying of our institute is the first author of the paper, and researcher Wang Fengzhong is the corresponding author

    .
    The research was funded by the central-level basic scientific research operating fee (Y2020LM05)

    .

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