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    Home > Active Ingredient News > Drugs Articles > The four-ring freeze-drying pharmaceutical freeze dryer process can be divided into five steps

    The four-ring freeze-drying pharmaceutical freeze dryer process can be divided into five steps

    • Last Update: 2022-04-29
    • Source: Internet
    • Author: User
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    Sihuan freeze-drying pharmaceutical freeze dryers are widely used in medicine, pharmacy, biological research, chemical drugs and bio-pharmaceuticals, Chinese herbal medicines, western medicine injections and other fields
    .

    The freeze-dried medicines are easy to store for a long time, and can be restored to the state before freeze-drying and maintain the original biochemical properties after adding water
    .

    Four-ring freeze-drying pharmaceutical freeze-drying machine refers to the drying method of freezing the drug solution at low temperature, and then sublimating and drying it under vacuum conditions to remove ice crystals
    .

    The process can be mainly divided into five steps: drug preparation, pre-freezing, primary drying (sublimation drying), secondary drying (desorption drying), and sealed preservation
    .

    After the drug is freeze-dried according to the above method, it can be stored at room temperature for a long time in the dark.
    When needed, add distilled water or physiological saline to make a suspension, which can restore the state before freeze-drying
    .

    Four-ring freeze-drying pharmaceutical freeze-drying machine is mainly composed of compressor, oil separator, drying filter, condenser, vapor-liquid separator, return air filter, refrigerant, intercooler, solenoid valve, sight glass, hand It is composed of valve (top cover valve), expansion valve, evaporator (plate exchanger, rear box condenser coil), pressure gauge, pressure control relay, CPCE (energy regulator), safety valve, refrigeration pipeline and other components
    .

    During the use of the four-ring freeze-drying pharmaceutical freeze-drying machine, the preparation of samples should expand their surface area as much as possible, and be free of acid, alkali and volatile organic solvents; the samples must be completely frozen into ice before operation, if there is residual liquid It will cause gasification jet; note that the cold trap is about -65°C, which can be used as a low-temperature refrigerator, but must wear thermal gloves to prevent frostbite; before starting the vacuum pump, check whether the water outlet valve control is tightened, and the inflation valve can be closed.
    Whether the contact surface between the cover and the rubber ring is clean and free of dirt, and has a good environmental seal; under normal circumstances, the machine should not be used continuously for more than 48 hours; during the freezing process, the temperature of the sample gradually decreases, and the sample can be taken out to warm up for a while After the time, continue drying to shorten the drying time
    .

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