echemi logo
  • Product
  • Supplier
  • Inquiry
    Home > Medical News > Medical Science News > The genetic mechanism of Alzheimer's disease family in China has been revealed

    The genetic mechanism of Alzheimer's disease family in China has been revealed

    • Last Update: 2021-01-04
    • Source: Internet
    • Author: User
    Search more information of high quality chemicals, good prices and reliable suppliers, visit

    alzheimer's disease (AD) is a common disease in the elderly population, but familial Alzheimer's disease (FAD) is rare. However, because FAD patients focus on all the pathophysiological characteristics of AD disease, it has become the industry experts to study the pathogenesis of AD the best population.
    since the first AD patients were reported in 1906, important pathogenesis advances such as the A-beta theory, the tau theory, the inflammatory theory, etc. have all come from THED research. Therefore, most scholars generally agree that the study of AD needs to start with THED.
    Recently, Jia Jianping, a professor at Xuanwu Hospital of Capital Medical University, conducted a 17-year follow-up study of 404 Chinese FAD family departments, which revealed the genetic law of the disease in depth and provided a theoretical basis for AD's genetic intervention and gene therapy in China. The study was published in Alzheimer's and Dementia.
    that the team has been building the country's largest FAD registration network (CFAN) since 2002 to collect FAD cases across the country. By September 2019, a total of 404 family members and more than 3,700 family members had been collected. CFAN is also currently the world's largest FAD registration network.
    researchers found 50 PSENs/APP mutations, 11 of which were first reported internationally, indicating Chinese heterogeneity of pathogenesis with other races. "But 83.17 percent of the 404 family lineages do not carry the known gene PSENs/APP mutation, and there are still a number of unknown genes to be excavated, which will have an important impact on the discovery of Chinese AD's characteristic genes." Jia jianping said the team reported China's first FAD in 2005, which opened the way for genetic research into AD. After long-term systematic research, they gradually solved the mystery of Chinese FAD gene mutation, which has an important impact on understanding the pathogenesis of Chinese AD, but also for chinese AD genetic intervention and gene therapy to provide ideas and platforms.
    the future, it may be expected to start with editing, reverse genetic defects, and find new breakthroughs for the eventual cure of AD. Jia Jianping said. (Source: Zhang Siwei, China Science Journal)
    relevant paper information:
    This article is an English version of an article which is originally in the Chinese language on and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.
    Related Articles

    Contact Us

    The source of this page with content of products and services is from Internet, which doesn't represent Echemi's opinion. If you have any queries, please write to It will be replied within 5 days.

    Moreover, if you find any instances of plagiarism from the page, please send email to with relevant evidence.