The genetic variant of TMEM106B causes the elderly brain to age faster than their peers for 12 years.

Researchers at Columbia University Medical Center have found a common genetic mutation that dramatically accelerates brain aging in older adults and may increase the risk of neurodegenerative diseases.
related research was published online on the 15th in the journal Cell Systems.
in real life, some older people look older than their peers, while others are younger, and this aging difference is also present in the pre-cortical layer of the human brain.
preletetal cortical layer is the brain's advanced cognitive center, playing a key role in the advanced functions of the brain, such as reasoning cognition, and its aging differences have a significant impact on the behavior of the elderly.
the study, researchers analyzed genetic data from brain samples from more than 1,900 autopsies of the deceased.
By analyzing the transcription groups of these people, they mapped the standard images of brain biology for a given age group, and then compared the differences between the individual transcription groups and the peer groups to see whether a person's prelental cortical layer was older or younger than its peers.
, the researchers analyzed each person's genome to look for genetic variants associated with aging.
found that a genetic mutation called TMEM106B is closely related to brain aging.
the gene variant is more common, with one-third of people having two copies of the mutation.
researchers point out that when a person is about 65 years old, the TMEM106B gene variant begins to work, and people with two "poor quality" copies age more in the forehead cortical layer than those who have a normal copy of the gene for 12 years.
addition, the researchers found another genetic variant associated with brain aging in the granulated protein pregeneral gene, but it did not work as well as the TMEM106B gene.
particulate protein and TMEM106B are located on different chromosomes, but are involved in the same signaling pathways, both of which are associated with the rare neurodegenerative disease called temporal dementia.
The study did not confirm the role of these two variants in neurodegenerative diseases, but the researchers noted that individual genes increase the risk of neurodegenerative diseases, but are not the main cause of disease, aging is the most important risk factor for neurodegenerative diseases.
, genetic variants associated with brain aging may be found as new targets for the prevention or treatment of age-related brain diseases.
is the common destiny of the citizens of the earth, but it is not easy to get there smoothly.
neurodegenerative lesions, represented by Alzheimer's disease, have become the common "enemy" of the world's elderly, and the relevant pathogenesis is an important node on the road to alleviating pain and even curing related diseases.
neuroscience-based brain science research is not only a hot area in the current international scientific and technological frontier, it may become the "ultimate frontier" of human understanding of nature and humanity itself.
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