The Genome Labeling Program GTP program will be led by Chinese scientists.

The Human Genome Project (HGP) took 13 years and cost $3 billion to pass through the human genetic "code", but many life problems remain unanswered.
for example, the genome is the same, but the cells are divided into different organs, what happens inside? What happens to cells before, during, and after cancer? ...... Are these dynamic life "programs" likely to be read? On May 23, the Xiangshan Science Conference held a symposium in Shanghai on the theme of the Genome Labeling Program (GTP), which recommended the launching of the Genome Labeling Program, which is fully led by Chinese scientists, to collaborate on the completion of complex life-process readings.
"Life is a dynamic program.
genome decoding is static, it is difficult to reflect the essence of life.
the post-genome era, people began to explore the interaction and action of biological macromolecules in the course of life. "
But such research is still in the "blind image" stage, let alone mastering its laws, said Li Jinsong, a researcher at the Institute of Biochemistry and Cell Biology at the Chinese Academy of Sciences.
based on the developing GTP platform, it is possible to track life activities at the molecular level with high precision and accuracy. "We are aiming at solving major scientific problems and using the GTP platform to push the limits of human cognition of life by forming a scientific community," said Li Lin, a member of the Chinese Academy of Sciences at the
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at the same time, the implementation of GTP projects will lead to the development of related scientific fields, such as labeling technology, protein analysis technology, etc., will eventually promote the overall level of life science research.
" in addition, the GTP program is expected to lead humans into the "no where it is" in life science research, such as the vast field of brain science, the unexplained "gene desert" and so on.
Chinese scientists led the launch of HGP based on humanmastergene sequencing technology - Sanger sequencing, GTP's launch is also based on the invention of new technology, that is, Chinese scientists in the field of "artificial sperm cells" mediated semi-cloning has the world's leading technology, patents and research.
", "So it makes sense that the GTP program is led by our scientists."
, " li said, the current protein analysis technology is difficult to reflect the life function of proteins in real time.
Chinese scientists have developed "artificial sperm cells" to return the study of proteins to animal living, greatly improving the efficiency of gene-editing animal models and ensuring the accuracy of gene editing. "We integrate a specific label sequence into a coded protein gene sequence in an artificial sperm cell by gene editing, and the gene manipulation is accurately reflected in semi-cloned mice,"
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" Li Jinsong said, in animal living to study proteins, in the body, in situ, real-time, dynamic.
set up a platform to target major scientific issues" this is a holistic project, so standards must be harmonized at the outset to ensure data consistency.
" Li Jinsong introduced, GTP has been the Chinese Academy of Sciences strategic pilot Class B special and Shanghai Science and Technology Commission project support, has been set up in the Biochemical and Cell Institute GTP research and development center, developed standard operating procedures.
at present, GTP Research and Development Center has obtained more than 500 label "artificial sperm cell" lines and more than 140 labeled mouse line.
thousand slong journey, starting with the beginning of the GTP program from the platform to start. "We plan to label protein genes for the genome range within 5 to 10 years, obtain a 'artificial sperm cell' bank for the genome (about 25,000 genes), and obtain more than 5,000 gene-to-human,"
, forming an internationally influential experimental animal research and development platform.
," Li said. "We have already carried out relevant cooperation, including some international cooperation, "
.
" Li Jinsong said, GTP research and development center is also preparing for the construction of relevant network platform, research team will soon be able to apply through the network to submit cooperation.
life scientists can use this platform for the first time to carry out large-scale scientific research programs, such as mapping accurate protein maps of development, exploring proteins associated with the onset of tumors or other diseases, and providing drug targets and new methods of diagnosis and treatment for precision treatment.
the large number of tasks, innovation and collaboration will be well suited to describe gtP's work tasks throughout the well-known "iceberg theory".
Li Jinsong explained that if 25,000 functional genes are the "icebergs" that surface, then the corresponding protein, protein conformation changes, protein regulation pathways and other research tasks are larger icebergs under the surface of the water, the mass is likely to be hundreds of times the surface of the water.
Although the Institute of Biochemistry and Cell Research of the Chinese Academy of Sciences has set up a special GTP research and development center in order to promote GTP, "the overall work of the mass, can not be a unit can complete."
," Li said.
in addition, the extension to the iceberg also needs a "knowledge base", a cell pathway or protein characteristics of the research group, supplemented by the new technology "support", will be "like a tiger", so the GTP program needs to have a life science research foundation of the scientific research team, of course, there will be a certain entry threshold.
" new technologies will continue to innovate as the program goes on.
" Li Xiangsheng, a researcher at the Institute of Biochemistry and Cells of the Chinese Academy of Sciences, said, for example, the GTP2.0 era may explore the use of fluorescent markers, and ultimately visualize protein expression, with scientists not having to confirm the amount of protein expression in the strip, and may even be qualitatively quantified through fluorescence.
will show the human eyes will be not only the expression and translation of human 25,000 encoded protein genes, but also the "time series" of protein expression, and even watch the life from fertilized eggs into a "road map" of life process.
Source: Science Daily.